65128-66-7

Basic information

• Product Name: Thiazolo[4,5-c]pyridine-2-thiol
• Synonyms: Thiazolo[4,5-c]pyridine-2-thiol;Thiazolo[4,5-c]pyridine-2(3H)-thione;[1,3]thiazolo[4,5-c]pyridine-2-thiol
• CAS NO: 65128-66-7
• Molecular Formula: C₆H₄N₂S₂
• Molecular Weight: 168.244
• Mol File: 65128-66-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 343.857°C at 760 mmHg
• Flash Point: 161.759°C
• Appearance: /
• Density: 1.57g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.802
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: Thiazolo[4,5-c]pyridine-2-thiol(CAS DataBase Reference)
• NIST Chemistry Reference: Thiazolo[4,5-c]pyridine-2-thiol(65128-66-7)
• EPA Substance Registry System: Thiazolo[4,5-c]pyridine-2-thiol(65128-66-7)

Safety Data

• Hazardous Substances Data: 65128-66-7(Hazardous Substances Data)

Usage

General Description

Thiazolo[4,5-c]pyridine-2-thiol is a chemical compound with a molecular structure containing a thiazole ring fused to a pyridine ring, and a sulfur atom attached to the second carbon of the thiazole ring. It is used in various organic synthesis reactions and can also serve as a building block for the construction of biologically active molecules and pharmaceuticals. Thiazolo[4,5-c]pyridine-2-thiol has demonstrated potential as a promising candidate for antifungal and antibacterial drugs due to its unique structure and activity against certain pathogens. Additionally, it has been studied for its potential use in materials science, such as in the development of organic semiconductors and optoelectronic devices.

InChI:InChI=1/C6H4N2S2/c9-6-8-4-3-7-2-1-5(4)10-6/h1-3H,(H,8,9)

Upstream product

• 75-15-0 carbon disulfide 
• 13091-23-1 4-chloro-3-nitropyridine 
• 38240-23-2 3-aminopyridine-4(1H)-thione 
• 20511-15-3 3-amino-4-chloropyridine 
• 140-89-6 potassium ethyl xanthogenate 

Downstream Products

• 857970-39-9 3H-thiazolo[4,5-c]pyridin-2-one 
• 65128-67-8 2-(methylthio)thiazolo[4,5-c]pyridine 
• 159635-89-9 (6R,7R)-7-{2-[(Z)-1-tert-Butoxycarbonyl-1-methyl-ethoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-3-(thiazolo[4,5-c]pyridin-2-ylsulfanylmethyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 159635-88-8 (6R,7R)-7-{2-[(Z)-Benzhydryloxycarbonylmethoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-3-(thiazolo[4,5-c]pyridin-2-ylsulfanylmethyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 159635-90-2 (6R,7R)-7-{2-[(Z)-(S)-1-Benzhydryloxycarbonyl-ethoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-3-(thiazolo[4,5-c]pyridin-2-ylsulfanylmethyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 884860-63-3 2-chlorothiazolo[4,5-c]pyridine 
• 1431300-94-5 N-(4-bromophenyl)thiazolo[4,5-c]pyridin-2-ylamine 
• 1431300-96-7 2,2-dimethyl-3-(5-(4-(thiazolo[4,5-c]pyridin-2-ylamino)phenyl)pyrimidin-2-yloxy)propionic acid methyl ester 

Relevant articles and documents

General Entry into o-,o′-Heteroatom-Linked N-(Hetero)aryl-Imidazole Motifs by Gold-Catalysed Formal [3+2]-Dipolar Cycloaddition

A general redox-neutral approach into the o-,o′-heteroatom-linked N-(hetero)aryl-imidazole family of heteroaromatics has been developed. New types of heteroatom substituted carbimidoyl nitrenoids are efficiently realised from robust, bench-stable N-(heteroaryl)-pyridinium-N-aminides by formal gold-catalysed [3+2]-dipolar cycloadditions across ynamides. Broad structural variety and functional group tolerance allows rapid access into diverse functionalised scaffolds, as exemplified by the preparation of 8 different heteroaromatic cores. (Figure presented.).

COMPOUNDS FOR MODULATING TRPV3 FUNCTION

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β-lactam compounds and process for producing the same

Novel β-lactam compound of the formula [1]: wherein R1is lower alkyl or hydroxy-substituted lower alkyl, R2is H or lower alkyl, X is O or, S, R3is H, metal or protecting group, W is a 6- or 7-membered nitrogen-containing heterocycle optionally being substituted at carbon atoms. Said β-lactam compound shows excellent antibacterial activity against Gram-positive bacteria, particularly against methicillin-resistantStaphylococcus aureusand methicillin-resistant and coagulase-negativeStaphylococcus aureus.