652153-35-0 Usage
Medical Use
Treatment of advanced renal cell carcinoma (RCC) and gastrointestinal stromal tumors (GISTs)
Class
Tyrosine kinase inhibitor
Mechanism of Action
Blocks abnormal proteins signaling cancer cells to grow
Targets
Vascular endothelial growth factor receptor (VEGFR)
Platelet-derived growth factor receptor (PDGFR)
Stem cell factor receptor (KIT)
Effect
Interferes with pathways promoting tumor growth
Resultant Actions
Decrease in cell proliferation
Inhibition of blood vessel formation within tumors
Impact
Slows tumor progression
Check Digit Verification of cas no
The CAS Registry Mumber 652153-35-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,5,2,1,5 and 3 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 652153-35:
(8*6)+(7*5)+(6*2)+(5*1)+(4*5)+(3*3)+(2*3)+(1*5)=140
140 % 10 = 0
So 652153-35-0 is a valid CAS Registry Number.
652153-35-0Relevant articles and documents
Synthesis and identification of [1,3,5]triazine-pyridine biheteroaryl as a novel series of potent cyclin-dependent kinase inhibitors
Kuo, Gee-Hong,DeAngelis, Alan,Emanuel, Stuart,Wang, Aihua,Zhang, Yan,Connolly, Peter J.,Chen, Xin,Gruninger, Robert H.,Rugg, Catherine,Fuentes-Pesquera, Angel,Middleton, Steven A.,Jolliffe, Linda,Murray, William V.
, p. 4535 - 4546 (2007/10/03)
On the basis of previous studies, we identified pyrazine-pyridine A as a potent vascular endothelial growth factor inhibitor and pyrimidine-pyridine B as a moderately potent cyclin dependent kinase (CDK) inhibitor. A proposed combination of CGP-60474 and
