65269-96-7

Basic information

• Product Name: hexane-1-sulphonyl fluoride
• Synonyms: hexane-1-sulphonyl fluoride;1-Hexanesulfonyl fluoride;Hexane-1-sulfonyl fluoride;Hexane-1-sulfonyl=fluoride;Einecs 265-663-2
• CAS NO: 65269-96-7
• Molecular Formula: C6H13FO2S
• Molecular Weight: 168.2296232
• EINECS: 265-663-2
• Mol File: 65269-96-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 221.2°C at 760 mmHg
• Flash Point: 87.6°C
• Appearance: /
• Density: 1.092g/cm³
• Vapor Pressure: 0.161mmHg at 25°C
• Refractive Index: 1.417
• CAS DataBase Reference: hexane-1-sulphonyl fluoride(CAS DataBase Reference)
• NIST Chemistry Reference: hexane-1-sulphonyl fluoride(65269-96-7)
• EPA Substance Registry System: hexane-1-sulphonyl fluoride(65269-96-7)

Safety Data

• Hazardous Substances Data: 65269-96-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H13FO2S/c1-2-3-4-5-6-10(7,8)9/h2-6H2,1H3

Upstream product

• 14532-24-2 1-hexanesulfonyl chloride 
• 2832-45-3 sodium hexyl sulfate 
• 773-15-9 1,2,2-trifluoro-2-hydroxy-1-trifluoromethylethanesulfonic acid sultone 
• 542-69-8 1-iodo-butane 
• 677-25-8 ethylenesulfonyl fluoride 

Relevant articles and documents

An Easy, General and Practical Method for the Construction of Alkyl Sulfonyl Fluorides

A visible light-induced reductive addition of 1°, 2° and 3° alkyl iodides to ethenesulfonyl fluoride, employing Hantzsch ester as a hydrogen source at room temperature was developed. This method featured a wide substrate scope and great functional group compatibility, providing facile and robust process to alkyl sulfonyl fluorides including enzyme inhibitors, natural products and drugs derivatives in up to 99percent yield. Further derivatization of resultant aliphatic sulfonyl fluorides was also achieved through sulfur fluoride exchange (SuFEx) reactions to deliver sulfonates and sulfonamides as privileged motifs for medicinal chemistry. (Figure presented.).