65271-75-2

Basic information

• Product Name: 1,4-bis[(5-hydroxypentyl)amino]anthracene-9,10-dione
• Synonyms: 1,4-Bis((5-hydroxypentyl)amino)-9,10-anthracenedione; 9,10-Anthracenedione, 1,4-bis((5-hydroxypentyl)amino)-
• CAS NO: 65271-75-2
• Molecular Formula: C₂₄H₃₀N₂O₄
• Molecular Weight: 410.506
• Mol File: 65271-75-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 677.2°C at 760 mmHg
• Flash Point: 363.4°C
• Density: 1.262g/cm³
• Vapor Pressure: 2.88E-19mmHg at 25°C
• Refractive Index: 1.646
• CAS DataBase Reference: 1,4-bis[(5-hydroxypentyl)amino]anthracene-9,10-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-bis[(5-hydroxypentyl)amino]anthracene-9,10-dione(65271-75-2)
• EPA Substance Registry System: 1,4-bis[(5-hydroxypentyl)amino]anthracene-9,10-dione(65271-75-2)

Safety Data

• Hazardous Substances Data: 65271-75-2(Hazardous Substances Data)

Usage

Family

Anthraquinone

Source

Synthetic chemical compound derived from anthracene-9,10-dione

Potential Application

Anti-cancer agent

Mechanism of Action

Inhibits cancer cell growth by inducing apoptosis and disrupting the cell cycle

Additional Potential

Photosensitizer for photodynamic therapy

Current Status

Research ongoing, not approved for clinical use

Upstream product

• 476-60-8 leucoquinizarin 
• 2508-29-4 5-hydroxypentylamine 
• 81-64-1 1,4-dihydroxy-9,10-anthracenedione 

Relevant articles and documents

Synthesis of mono- and bis-substituted anthraquinones as inhibitors of human telomerase

A number of anthraquinone derivatives have been synthesized in good yield and tested for their ability to inhibit the enzymes telomerase and Taq polymerase using a modified telomeric repeat amplification protocol. In addition, all the synthesized compounds were screened against a panel of ovarian carcinoma cell lines (A2780, CH1 and SKOV-3) to determine their cytotoxicity. All compounds tested inhibited telomerase at a concentration of 10 μM, but showed negligible inhibition of Taq polymerase. None of the compounds tested displayed significant general cell toxicity in ovarian cancer cell lines. The synthesized compounds are potential selective inhibitors of human telomerase.