65275-12-9

Basic information

• Product Name: 5-HYDROXYPYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 5-HYDROXYPYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER;Ethyl 5-hydroxypicolinate
• CAS NO: 65275-12-9
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.163
• Mol File: 65275-12-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 375.4°C at 760 mmHg
• Flash Point: 180.8°C
• Appearance: /
• Density: 1.233g/cm³
• Vapor Pressure: 3.61E-06mmHg at 25°C
• Refractive Index: 1.541
• PKA: 8.33±0.10(Predicted)
• CAS DataBase Reference: 5-HYDROXYPYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-HYDROXYPYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER(65275-12-9)
• EPA Substance Registry System: 5-HYDROXYPYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER(65275-12-9)

Safety Data

• Hazardous Substances Data: 65275-12-9(Hazardous Substances Data)

Usage

General Description

5-Hydroxypyridine-2-carboxylic acid ethyl ester is a chemical compound with the molecular formula C8H9NO3. It is an ethyl ester derivative of 5-hydroxypyridine-2-carboxylic acid, a pyridine derivative. This chemical is commonly used in the pharmaceutical industry as an intermediate in the synthesis of various drugs and pharmaceutical compounds. It is known for its role in the production of anti-inflammatory and anti-oxidant medications. Additionally, it has been studied for its potential therapeutic effects in various diseases and conditions, making it an important compound in medical research and drug development.

InChI:InChI=1/C8H9NO3/c1-2-12-8(11)7-4-3-6(10)5-9-7/h3-5,10H,2H2,1H3

Upstream product

• 41288-96-4 6-chloropyridine-3-ol 
• 64-17-5 ethanol 
• 201230-82-2 carbon monoxide 
• 15069-92-8 5-hydroxypicolinic acid 

Downstream Products

• 1254781-36-6 5-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridine-2-carboxylic acid ethyl ester 
• 1254781-42-4 5-[3-(4-fluoro-phenyl)-5-((E)-styryl)-isoxazol-4-ylmethoxy]-pyridine-2-carboxylic acid ethyl ester 
• 1463501-46-3 (2S,5R)-5-(benzyloxyamino)piperidin-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester 
• 1416134-47-8 (2S,5R)?5?[(benzyloxy)amino]piperidine?2?carboxylate 
• 1416134-49-0 (2S,5R)-5-(benzyloxyamino)-piperidine-2-carboxylic acid amide 
• 1192651-49-2 (1R,2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 
• 1192500-31-4 (2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate 
• 1192651-80-1 ({[(2S,5R)-2-carbamoyl-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3,2,1]-oct-6-yl]oxy}sulfonyl)tetrabutylammonium salt 
• 1192491-61-4 (2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt 

Relevant articles and documents

Synthetic methods for (1S,4S)-2,5-diazabicyclo[2.2.2] octane and derivatives thereof

The invention discloses synthetic methods for (1S,4S)-2,5-diazabicyclo[2.2.2] octane and derivatives thereof, and belongs to the field of organic chemical synthesis. According to the method, 5-hydroxypyrazine-2-formate as a compound II is taken as a raw material, and high selectivity of a reaction is guaranteed through selective protection of hydroxyl and amino groups. A product obtained with the method has high yield, the by-product content is low, and the method is applicable to industrial production.

IMIDAZOPYRIDINE COMPOUND

The present invention provides an imidazopyridine compound represented by formula (I), wherein R1 and R2 each independently represent a C1-6 alkyl group et al; R3 and R4 each independently represent a hydrogen atom, a methyl et al; Ar1 is a divalent substituent representing a monocyclic or bicyclic, 3- to 8-membered aromatic or aliphatic heterocyclic group et al; Ar2 represents an aromatic carbocyclic group, or an aromatic heterocyclic group; W represents -(CH2)m et al, and m indicates an integer of from 0 to 10. This compound acts as a melanin concentrating hormone receptor antagonist, and is useful as treating agents for obesity.