65287-34-5

Basic information

• Product Name: 2-Chloropyridine-4-carbonyl chloride
• Synonyms: TIMTEC-BB SBB005463;2-CHLORO-ISONICOTINOYL CHLORIDE;2-CHLOROPYRIDINE-4-CARBONYL CHLORIDE;BUTTPARK 43\57-04;4-Pyridinecarbonyl chloride, 2-chloro- (9CI);2-Chloropyridine-4-carbonyl chloride, 95+%;2-Chloropyridine-4-carbonyl chloride ,97%;2-Chloro-4-pyridinecarbonyl chloride
• CAS NO: 65287-34-5
• Molecular Formula: C₆H₃Cl₂NO
• Molecular Weight: 176
• EINECS: 214-589-6
• Product Categories: ACIDHALIDE
• Mol File: 65287-34-5.mol
• Article Data: 40

Chemical Properties

• Boiling Point: 144 °C
• Flash Point: >110℃
• Appearance: /
• Density: 1.418
• Vapor Pressure: 0.0228mmHg at 25°C
• Refractive Index: n20/D1.566
• Storage Temp.: Store under nitrogen
• PKA: -1.84±0.10(Predicted)
• CAS DataBase Reference: 2-Chloropyridine-4-carbonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloropyridine-4-carbonyl chloride(65287-34-5)
• EPA Substance Registry System: 2-Chloropyridine-4-carbonyl chloride(65287-34-5)

Safety Data

• Hazard Codes: C
• Statements: 34-29-14-25
• Safety Statements: 26-36/37/39-8-45-30-23
• RIDADR: 3265
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 65287-34-5(Hazardous Substances Data)

Usage

Uses

2-Chloroisonicotinoyl Chloride can be used to prepare insecticides.

InChI:InChI=1/C6H3Cl2NO/c7-5-3-4(6(8)10)1-2-9-5/h1-3H

Upstream product

• 6313-54-8 2-chloroisonicotinic acid, 
• 13602-12-5 Isonicotinic acid N-oxide 
• 5398-44-7 2,6-dichloropyridine-4-carboxylic acid 
• 383865-57-4 4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine 
• 147-85-3 L-proline 
• 79-37-8 oxalyl dichloride 

Downstream Products

• 100859-84-5 2-chloro-4-pyridine carboxamide 
• 123412-45-3 N-<(2-chloropyridin-4-yl)carbonyl>pyrrolidine-2-carboxylic acid 
• 100704-10-7 (2-chloropyridin-4-yl)methanol 
• 439931-33-6 2-chloro-N-isopropylisonicotinamide 
• 295310-31-5 3-[5-(2-Chloropyrid-4-ylcarbonylamino)-2-methylphenyl]-6-(4-methylpiperazin-1-yl)-3,4-dihydroquinazolin-4-one 
• 918299-67-9 2-benzyloxy-4-bromomethylpyridine 
• 156367-50-9 (2-benzyloxypyridin-4-yl)methanol 
• 918299-73-7 (2-benzyloxypyridin-4-yl)methylphosphonic acid diethyl ester 
• 918299-74-8 [(2-benzyloxypyridin-4-yl)difluoromethyl]phosphonic acid diethyl ester 
• 918299-71-5 {1-[3,4-bis(benzoyloxy)-5-(benzoyloxymethyl)tetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyridin-4-yl}methylphosphonic acid dimethyl ester 
• 93639-43-1 2-chloro-3-(2,5-dimethoxybenzoyl)-4-pyridine carboxylic acid 
• 93639-41-9 1,3-dihydro-3-(2,5-dimethoxyphenyl)-4-chloro-3H-pyrido<3,4-e>furan-1-one 
• 93639-39-5 [2-Chloro-4-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-pyridin-3-yl]-(2,5-dimethoxy-phenyl)-methanol 
• 111424-44-3 4-Acetyl-3-(3-methoxy-benzyl)-1H-pyridin-2-one 

Relevant articles and documents

Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore

Inhibition of glucosylceramide synthase (GCS) is a major therapeutic strategy for Gaucher’s disease and has been suggested as a potential target for treating Parkinson’s disease. Herein, we report the discovery of novel brain-penetrant GCS inhibitors. Assessment of the structure-activity relationship revealed a unique pharmacophore in this series. The lipophilic ortho-substituent of aromatic ring A and the appropriate directionality of aromatic ring B were key for potency. Optimization of the absorption, distribution, metabolism, elimination, toxicity (ADMETox) profile resulted in the discovery of T-036, a potent GCS inhibitor in vivo. Pharmacophore-based scaffold hopping was performed to mitigate safety concerns associated with T-036. The ring opening of T-036 resulted in another potent GCS inhibitor with a lower toxicological risk, T-690, which reduced glucosylceramide in a dose-dependent manner in the plasma and cortex of mice. Finally, we discuss the structural aspects of the compounds that impart a unique inhibition mode and lower the cardiovascular risk.

Amide compound as well as preparation method and application thereof

The invention provides an amide compound as well as a preparation method and application thereof. The amide compound has a structure as shown in a formula I in the specification. The amide compound disclosed by the invention can have high insecticidal act

Synthesis of N-trifluoromethyl amides from carboxylic acids

Found in biomolecules, pharmaceuticals, and agrochemicals, amide-containing molecules are ubiquitous in nature, and their derivatization represents a significant methodological goal in fluorine chemistry. Trifluoromethyl amides have emerged as important functional groups frequently found in pharmaceutical compounds. To date, there is no strategy for synthesizing N-trifluoromethyl amides from abundant organic carboxylic acid derivatives, which are ideal starting materials in amide synthesis. Here, we report the synthesis of N-trifluoromethyl amides from carboxylic acid halides and esters under mild conditions via isothiocyanates in the presence of silver fluoride at room temperature. Through this strategy, isothiocyanates are desulfurized with AgF, and then the formed derivative is acylated to afford N-trifluoromethyl amides, including previously inaccessible structures. This method shows broad scope, provides a platform for rapidly generating N-trifluoromethyl amides by virtue of the diversity and availability of both reaction partners, and should find application in the modification of advanced intermediates.