65370-90-3

Basic information

• Product Name: 4-amino-1-[2,3-O-(1-methylethylidene)pentofuranosyl]-1,3,5-triazin-2(1H)-one
• CAS NO: 65370-90-3
• Molecular Formula: C₁₁H₁₆N₄O₅
• Molecular Weight: 284.2685
• Mol File: 65370-90-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 454.4°C at 760 mmHg
• Flash Point: 228.6°C
• Density: 1.78g/cm³
• Vapor Pressure: 3.63E-10mmHg at 25°C
• Refractive Index: 1.732
• CAS DataBase Reference: 4-amino-1-[2,3-O-(1-methylethylidene)pentofuranosyl]-1,3,5-triazin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-1-[2,3-O-(1-methylethylidene)pentofuranosyl]-1,3,5-triazin-2(1H)-one(65370-90-3)
• EPA Substance Registry System: 4-amino-1-[2,3-O-(1-methylethylidene)pentofuranosyl]-1,3,5-triazin-2(1H)-one(65370-90-3)

Safety Data

• Hazardous Substances Data: 65370-90-3(Hazardous Substances Data)

Upstream product

• 77-76-9 2,2-dimethoxy-propane 
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• 320-67-2 5-azacytidine 

Relevant articles and documents

The first silicon(iv) phthalocyanine-nucleoside conjugates with high photodynamic activity

A series of novel silicon(iv) phthalocyanines conjugated axially with different nucleoside moieties (uridine, 5-methyluridine, cytidine, and 5-N-cytidine derivatives) have been synthesized and evaluated for their photodynamic activities. The uridine-containing compound 1 exhibits the highest photocytotoxicity against HepG2 human hepatocarcinoma cells with an IC 50 value as low as 6 nM, which can be attributed to its high cellular uptake and non-aggregated nature in the biological media. This compound shows high affinity toward the mitochondria of HepG2 cells and causes cell death mainly through apoptosis upon illumination. The result indicates that 1 is a highly promising photosensitizer for photodynamic therapy.