65373-52-6

Basic information

• Product Name: Oxazole-2-carbaldehyde
• Synonyms: 1,3-Oxazole-2-carboxaldehyde;1,3-oxazole-2-carbaldehyde;RARECHEM AK ML 0184;OXAZOLE-2-CARBALDEHYDE;2-OXAZOLECARBOXALDEHYDE;2-Oxazolecarboxaldehyde (9CI)
• CAS NO: 65373-52-6
• Molecular Formula: C₄H₃NO₂
• Molecular Weight: 97.07
• Product Categories: Oxazoles, Isoxazoles & Benzoxazoles;Oxazoles, Isoxazoles & Benzoxazoles;ALDEHYDE;Aldehydes
• Mol File: 65373-52-6.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 182.546 °C at 760 mmHg
• Flash Point: 64.202 °C
• Appearance: /
• Density: 1.259 g/cm³
• Vapor Pressure: 1.099mmHg at 25°C
• Refractive Index: 1.519
• PKA: -1.86±0.10(Predicted)
• CAS DataBase Reference: Oxazole-2-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: Oxazole-2-carbaldehyde(65373-52-6)
• EPA Substance Registry System: Oxazole-2-carbaldehyde(65373-52-6)

Safety Data

• Hazard Codes: Xi,F
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 65373-52-6(Hazardous Substances Data)

Usage

General Description

Oxazole-2-carbaldehyde is a chemical compound with the molecular formula C5H5NO. It belongs to the class of organic compounds known as oxazole carbaldehydes. Oxazole-2-carbaldehyde is a pale yellow liquid with a strong and pungent odor. It is primarily used as a building block in the synthesis of various pharmaceuticals and agrochemicals. Its derivatives are also used in the production of dyes, perfumes, and flavoring agents. Oxazole-2-carbaldehyde is toxic and harmful if ingested, inhaled, or comes into contact with the skin, and proper precautions must be taken when handling this chemical.

InChI:InChI=1/C4H3NO2/c6-3-4-5-1-2-7-4/h1-3H

Upstream product

• 154093-80-8 2-oxazolyl lithium 
• 68-12-2 N,N-dimethyl-formamide 
• 288-42-6 oxazol 
• 4394-85-8 4-morpholinecarboxaldehyde 

Downstream Products

• 130551-92-7 (1,3-oxazol-2-yl)methanol 
• 916220-09-2 oxazol-2-yl(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)methanol 
• 866640-97-3 2-[2,6-dimethyl-4-[[(oxazol-2-ylmethyl)amino]methyl]phenoxy]-2-methylpropanoic acid ethyl ester 
• 23419-15-0 C₁₀H₇N₃O 
• 1219004-99-5 (4S)-3-[(2S,3S)-2-(biphenyl-4-ylmethoxy)-3-hydroxy-2-methyl-3-(1,3-oxazol-2-yl)propanoyl]-5,5-dimethyl-4-phenyl-1,3-oxazolidin-2-one 
• 1398718-70-1 C₁₅H₁₈BrN₃O 
• 1446183-03-4 5-amino-2-(oxazol-2-yl)-4-phenylthiazole 
• 929713-54-2 oxazol-5-yl(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)methanol 
• 1059544-51-2 (E)-2-styryloxazole 
• 1202248-72-3 (Z)-2-styryloxazole 

Relevant articles and documents

Effect of the positional isomerism on the photoreactivity of styryloxazoles

This paper describes the results obtained in the study of the photobehaviour of heteroanalogs of stilbene bearing an oxazole ring. The competitive relaxation processes (fluorescence, isomerization and cyclization) of the excited states of n-styryloxazoles (n = 2 and 4) were investigated and compared with the behaviour previously reported for n = 5. After preparation of the unknown compound with n = 4 and of its positional isomer with n = 2 (the latter with a new method of synthesis), their photobehaviour was firstly investigated in preparative conditions by NMR analysis to measure the chemical yields of their photoproducts. The study was then continued in mild irradiation conditions to measure the quantum yields of the competitive photoreactions in the primary irradiation steps. The effects of the position of the styryl group at the oxazole ring, the relative abundance of the various conformers and the possible formation of intramolecular H-bonds on the deactivation pathways are described. Quantum-mechanical Hyperchem calculations proved to be very useful to describe the conformational equilibria and the role of conformers on photoreactivity while more refined DFT calculations on the Z isomers allowed to explain the structure dependent competition between their isomerization/cyclization processes. The effect of the replacement of the phenyl ring with a second heteroaromatic group of electron donor character was investigated for the 5-(2-(furan-2-yl) ethenyl) oxazole.

INDAZOLE DERIVATIVES USEFUL AS MELANIN CONCENTRATING RECEPTOR LIGANDS

The present invention relates to novel compounds, in particular, novel indazole that may be used as melanin concentrating hormone receptor ligands, methods of preparing such compounds, compositions containing such compounds, and methods of using such compounds to treat MCH related disorders.

4- (IH-INDAZOL-S-YL-AMINO)-QUINAZOLINE COMPOUNDS AS ERBB RECEPTOR TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF CANCER

A quinazoline derivative of the Formula I: wherein the substituents are as defined in the text for use in the production of an anti proliferative effect which effect is produced alone or in part by inhibiting erbB2 receptor tyrosine kinase in a warm blood