654071-76-8Relevant articles and documents
Design and synthesis of a novel family of triazine-based inhibitors of sorbitol dehydrogenase with oral activity: 1-{4-[3R,5S-dimethyl-4-(4-methyl-[1,3,5]triazin-2-yl)-piperazin-1-yl]-[1,3,5] triazin-2-yl}-(R) ethanol
Mylari, Banavara L.,Withbroe, Gregory J.,Beebe, David A.,Brackett, Nathaniel S.,Conn, Edward L.,Coutcher, James B.,Oates, Peter J.,Zembrowski, William J.
, p. 4179 - 4188 (2003)
Two new templates, (R) 2-hydroxyethyl-pyridine and (R) 2-hydroxyethyl-triazine, were used to design novel sorbitol dehydrogenase inhibitors (SDIs). The design concept included spawning of these templates to function as effective ligands to the catalytic z
