654682-77-6

Basic information

• Product Name: N-METHOXY-N-METHYL-2-THIOPHEN-3-YL-ACETAMIDE
• Synonyms: N-METHOXY-N-METHYL-2-THIOPHEN-3-YL-ACETAMIDE
• CAS NO: 654682-77-6
• Molecular Formula: C₈H₁₁NO₂S
• Molecular Weight: 185.24344
• Mol File: 654682-77-6.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-METHOXY-N-METHYL-2-THIOPHEN-3-YL-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-METHOXY-N-METHYL-2-THIOPHEN-3-YL-ACETAMIDE(654682-77-6)
• EPA Substance Registry System: N-METHOXY-N-METHYL-2-THIOPHEN-3-YL-ACETAMIDE(654682-77-6)

Safety Data

• Hazardous Substances Data: 654682-77-6(Hazardous Substances Data)

Upstream product

• 6964-21-2 thiophen-3-yl-acetic acid 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 13781-65-2 2-(thiophen-3-yl)acetyl chloride 
• 1117-97-1 N,0-dimethylhydroxylamine 

Downstream Products

• 654672-63-6 (thien-3-ylmethyl)-(4-chlorophenyl)-ketone 
• 57279-49-9 1-phenyl-2-(thiophen-3-yl)ethan-1-one 
• 1233735-42-6 1-(1-phenyl-1H-imidazol-2-yl)-2-(thiophen-3-yl)ethan-1-one 
• 1356060-17-7 2-hydroxy-4-(2-oxo-6-phenyl-5-(thiophen-3-yl)-1,2,3,4-tetrahydropyridin-4-yl)benzoic acid 
• 1283117-02-1 4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-6-phenyl-5-(thiophen-3-yl)-3,4-dihydropyrimidin-2(1H)-one 
• 1283117-04-3 (R)-4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-6-phenyl-5-(thiophen-3-yl)-3,4-dihydropyrimidin-2(1H)-one 
• 1283117-03-2 (S)-4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-6-phenyl-5-(thiophen-3-yl)-3,4-dihydropyrimidin-2(1H)-one 
• 1283118-32-0 3-ethoxy-2-hydroxy-5-(2-oxo-6-phenyl-5-(thiophen-3-yl)-1,2,3,4-tetrahydropyrimidin-4-yl)benzonitrile 

Relevant articles and documents

Enantioselective Mannich Reaction Employing 1,3,5-Triaryl-1,3,5-triazinanes Catalyzed by Chiral-at-Metal Rhodium Complexes

Chiral-at-metal RhIII complexes catalyze the efficient enantioselective Mannich reaction of 2-acyl imidazoles with 1,3,5-triazinanes, affording the corresponding adducts in 81–99 % yield with up to >99 % enantioselectivity. This protocol performs with 0.1 mol-% of RhIII complex on gram scale without any loss in enantioselectivity.

Aerobic Asymmetric Dehydrogenative Cross-Coupling between Two C sp 3 -H Groups Catalyzed by a Chiral-at-Metal Rhodium Complex

A sustainable C-C bond formation is merged with the catalytic asymmetric generation of one or two stereocenters. The introduced catalytic asymmetric cross-coupling of two Csp3-H groups with molecular oxygen as the oxidant profits from the oxidative robustness of a chiral-at-metal rhodium(III) catalyst and exploits an autoxidation mechanism or visible-light photosensitized oxidation. In the latter case, the catalyst serves a dual function, namely as a chiral Lewis acid for catalyzing enantioselective enolate chemistry and at the same time as a visible-light-driven photoredox catalyst. Green stuff: A sustainable C-C bond formation is merged with the catalytic asymmetric generation of one or two stereocenters by combining asymmetric enolate chemistry with either autoxidation or visible-light photosensitized oxidation. The robustness of a chiral-at-metal rhodium(III) catalyst serves to facilitate the reaction. PMP=para-methoxyphenyl, TFA=trifluoroacetic acid.

NOVEL DIHYDROPYRIMIDIN-2(1H)-ONE COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS

The present invention is directed to novel dihydropyrimidin-2(1H)-one compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.