65569-34-8

Basic information

• Product Name: Benzamide, 5-chloro-4-[[2-(4-chlorophenoxy)-1-oxopropyl]amino]-N-[2-(diethylamino )ethyl]-2-methoxy-
• CAS NO: 65569-34-8
• Molecular Formula: C23H29Cl2N3O4
• Molecular Weight: 482.407
• Mol File: 65569-34-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzamide, 5-chloro-4-[[2-(4-chlorophenoxy)-1-oxopropyl]amino]-N-[2-(diethylamino )ethyl]-2-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 5-chloro-4-[[2-(4-chlorophenoxy)-1-oxopropyl]amino]-N-[2-(diethylamino )ethyl]-2-methoxy-(65569-34-8)
• EPA Substance Registry System: Benzamide, 5-chloro-4-[[2-(4-chlorophenoxy)-1-oxopropyl]amino]-N-[2-(diethylamino )ethyl]-2-methoxy-(65569-34-8)

Safety Data

• Hazardous Substances Data: 65569-34-8(Hazardous Substances Data)

Upstream product

• 364-62-5 metoclopramide 
• 4878-20-0 2-(4-Chlorophenoxy)propionic acid chloride 
• 3307-39-9 2-(4-chlorophenoxy)propionic acid 

Relevant articles and documents

Cloxacepride and related compounds: A new series of orally active antiallergic compounds

4-[(p-Chlorophenoxy)acetyllamino]-5-chloro-2-methoxy-N-[2-(diethylamino)ethyl]benzamide (cloxacepride) exhibited substantial oral antiallergic potential in a reaginic PCA test in rats over a wide range of antigenic challenge times. Available reference compounds with oral activity, such as doxantrazole and 7-(2-hydroxyethoxy)-9-oxo-xanthene-2-carboxylic acid (AH 7725, 4) were active only when administered 15 min before challenge: 4, in particular, was not consistent in effect. Oral ED50 values for cloxacepride of 46-49 mg/kg were comparable to that of theophylline and to an intravenous injection of 2 mg/kg of disodium chromoglycate (DSCG) followed by immediate challenge. Following oral ED50 doses, 1 showed slower onset and longer duration of action than theophylline. The absence of inhibition of systemic anaphylaxis and of antihistaminic activity suggests specific effect for reaginic antigen antibody reactions. Structure-activity relationships of various chemical modifications were investigated and discussed in terms of essential substituents.