65635-85-0 Usage
Description
Cbz-N-Methyl-D-leucine is a chemical compound derived from N-methyl-D-leucine, an amino acid. It is a white to off-white crystalline powder with a molecular weight of 219.27 g/mol. The chemical structure of Cbz-N-Methyl-D-leucine consists of a carbobenzyloxy (Cbz) protecting group attached to the N-methyl-D-leucine amino acid. Cbz-N-Methyl-D-leucine is soluble in organic solvents such as methanol and dichloromethane.
Uses
Used in Pharmaceutical Research:
Cbz-N-Methyl-D-leucine is used as a building block in the creation of novel drug candidates. Its unique structure and properties make it a valuable component in the development of new pharmaceuticals.
Used in Peptide Synthesis:
Cbz-N-Methyl-D-leucine is used as a protecting group for amino acids during the chemical synthesis process. This prevents unwanted reactions and allows for the controlled formation of peptide bonds, which is crucial for the synthesis of complex peptide structures.
Used in Chemical Synthesis:
Cbz-N-Methyl-D-leucine is used as a protecting group in various chemical synthesis processes. Its carbobenzyloxy (Cbz) group can be selectively removed under mild conditions, allowing for the controlled formation of desired products without affecting other functional groups in the molecule.
Check Digit Verification of cas no
The CAS Registry Mumber 65635-85-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,6,3 and 5 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 65635-85:
(7*6)+(6*5)+(5*6)+(4*3)+(3*5)+(2*8)+(1*5)=150
150 % 10 = 0
So 65635-85-0 is a valid CAS Registry Number.
65635-85-0Relevant articles and documents
Synthesis of dysideaproline e using organocatalysis
Owusu-Ansah, Ernest,Durow, Amanda C.,Harding, John R.,Jordan, Angela C.,O'Connell, Susan J.,Willis, Christine L.
experimental part, p. 265 - 272 (2011/02/24)
(S)-4,4-Dichloro-3-methylbutanoic acid was prepared in 51% overall yield from commercially available starting materials using an organocatalytic transfer hydrogenation to 4,4-dichloro-3-methylbut-2-enal in the key step. The (S)-dichloro acid was used as an intermediate in the first total synthesis of dysideaproline E and a diastereomer confirming the structure of the natural product.
Pharmaceutical compositions containing didemnins
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, (2008/06/13)
This invention is directed to didemnin derivatives, including N-acyl congeners of didemnin A (DA); several DDB-type analogues of DA in which either pyruvic acid has been replaced (with phenylpyruvic acid or alphaketobutyric acid) or proline at position 8 has been replaced [with L-azetidine-2-carboxylic acid (AZT), L-pipecolic acid (Pip), 1-amino-1-carboxylic cyclopentane (acc 5), D-Pro or sarcosine (sar); and other cyclic depsipeptides related to the didemnins, which were isolated from a relatively polar extract of the tunicate T. solidum; namely the didemnins--X [(R)-3-hydroxy-decanoyl-(Gln) 3 -Lac-Pro didemnin A]; Y [(R)-3-hydroxy-decanoyl-(Gln) 4 -Lac-Pro didemnin A]; M (pGlu-Gln-Lac-Pro-didemnin A); N ([Tyr 5 ] didemnin B); nordidemnin N ([Tyr 5 ] nordidemnin B); and epididemnin A ([2S,4R-Hip 2 ] didemnin A).