65645-52-5

Basic information

• Product Name: 5-methoxypyridin-3-amine
• Synonyms: ethyl 2-(3-nitropyridin-4-yl)acetate;4-PYRIDINEACETIC ACID, 3-NITRO-, ETHYL ESTER;4-(3-Nitropyridine)ethyl acetate
• CAS NO: 65645-52-5
• Molecular Formula: C₉H₁₀N₂O₄
• Molecular Weight: 210.1867
• Mol File: 65645-52-5.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 318.902 °C at 760 mmHg
• Flash Point: 146.667 °C
• Appearance: /
• Density: 1.283 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.541
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.25±0.18(Predicted)
• CAS DataBase Reference: 5-methoxypyridin-3-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methoxypyridin-3-amine(65645-52-5)
• EPA Substance Registry System: 5-methoxypyridin-3-amine(65645-52-5)

Safety Data

• Hazardous Substances Data: 65645-52-5(Hazardous Substances Data)

Usage

General Description

5-methoxypyridin-3-amine is a chemical compound with the molecular formula C6H8N2O. It is a derivative of pyridine and contains a methoxy group and an amino group attached to the third carbon atom of the pyridine ring. 5-methoxypyridin-3-amine is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It has also shown potential as a building block for the development of new materials and chemical products. 5-methoxypyridin-3-amine is a versatile chemical that has applications in various industries, including pharmaceuticals, agriculture, and materials science.

InChI:InChI=1/C9H10N2O4/c1-2-15-9(12)5-7-3-4-10-6-8(7)11(13)14/h3-4,6H,2,5H2,1H3

Upstream product

• 54415-82-6 4-bis(ethoxycarbonyl)methyl-3-nitropyridine 
• 932702-14-2 1-(tert-butyl) 3-ethyl 2-(3-nitropyridin-4-yl)malonate 
• 626-64-2 pyridin-4-ol 
• 5435-54-1 4-hydroxy-3-nitropyridine 
• 13091-23-1 4-chloro-3-nitropyridine 
• 65645-51-4 ethyl 2-(3-nitropyridin-4-yl)-3-oxobutanoate 
• 2530-26-9 3-nitropyridine 
• 105-39-5 chloroacetic acid ethyl ester 

Downstream Products

• 65645-57-0 ethyl 2-(3-aminopyridin-4-yl)acetate 
• 1338219-56-9 ethyl {3-[(tert-butoxycarbonyl)amino]pyridin-4-yl}acetate 
• 486422-87-1 tert-butyl [4-(2-hydroxyethyl)pyridin-3-yl]carbamate 
• 1637752-28-3 spiro[cyclopropane-1,3'-pyrrolo[2,3-c]pyridin]-2'(1'H)-one 

Relevant articles and documents

Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion

RV521 is an orally bioavailable inhibitor of respiratory syncytial virus (RSV) fusion that was identified after a lead optimization process based upon hits that originated from a physical property directed hit profiling exercise at Reviral. This exercise encompassed collaborations with a number of contract organizations with collaborative medicinal chemistry and virology during the optimization phase in addition to those utilized as the compound proceeded through preclinical and clinical evaluation. RV521 exhibited a mean IC50 of 1.2 nM against a panel of RSV A and B laboratory strains and clinical isolates with antiviral efficacy in the Balb/C mouse model of RSV infection. Oral bioavailability in preclinical species ranged from 42 to >100% with evidence of highly efficient penetration into lung tissue. In healthy adult human volunteers experimentally infected with RSV, a potent antiviral effect was observed with a significant reduction in viral load and symptoms compared to placebo.

RESPIRATORY SYNCYTIAL VIRUS INHIBITORS

Compounds of Formula (I): wherein W is NR1A or CR1BR1B; Z is N or CH, R1A is C1-C3alkyl, C1-C3haloalkyl, C3-C4cycloalkyl or phenyl wherein cycloalkyl or phenyl is optionally mono-, di- or tri-substituted with substituents each independently selected from C1- C3alkyl, halo, amino and C1-C3alkoxy; the two R1B together with the carbon atom to which they are attached combine and form C3- C6cycloalkyl or heterocyclyl, wherein the cycloalkyl is substituent with C(=O)OR1C, NHC(=O)OR1C or NHS(=O)2 R1C, and the heterocyclyl is substituent with C(=O)R1C, C(=O)OR1C, S(=O)2 R1C, C(=O)NH2 or C(=O)NR1CR1C'; q, n, R1C, R2 and R3 are as defined herein, their use as inhibitors of RSV and related aspects.

SPIRO UREA COMPOUNDS AS RSV ANTIVIRAL COMPOUNDS

The invention concerns novel substituted spiro urea azetidinyl or piperidinyl compounds of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention furth