65685-50-9

Basic information

• Product Name: 5-bromobenzo[d]isoxazol-3-one
• Synonyms: 5-bromobenzo[d]isoxazol-3-one;5-broMo-1,2-benzoxazol-3-ol;5-BroMobenzo[d]isoxazol-3(2H)-one;5-Bromobenzo[d]isoxazol-3(2H)
• CAS NO: 65685-50-9
• Molecular Formula: C₇H₄BrNO₂
• Molecular Weight: 214.0162
• Mol File: 65685-50-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 202-203 °C
• Boiling Point: 360.6 °Cat 760mmHg
• Flash Point: 171.9 °C
• Appearance: /
• Density: 1.809 g/cm³
• Vapor Pressure: 1.06E-05mmHg at 25°C
• Refractive Index: 1.627
• Storage Temp.: 2-8°C
• PKA: 13.30±0.20(Predicted)
• CAS DataBase Reference: 5-bromobenzo[d]isoxazol-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromobenzo[d]isoxazol-3-one(65685-50-9)
• EPA Substance Registry System: 5-bromobenzo[d]isoxazol-3-one(65685-50-9)

Safety Data

• Hazardous Substances Data: 65685-50-9(Hazardous Substances Data)

Usage

General Description

5-bromobenzo[d]isoxazol-3-one is a chemical compound with the molecular formula C7H3BrNO2. It is a heterocyclic aromatic organic compound that contains both a benzene and isoxazole ring, and has a bromine atom attached to the benzene ring. This chemical is used in various research and scientific activities, including in the synthesis of other organic compounds and in pharmaceutical research. Its unique structure and properties make it valuable in the development of new materials and in the study of chemical reactions. Additionally, 5-bromobenzo[d]isoxazol-3-one may also have potential applications in the pharmaceutical industry for the development of new drugs and therapeutic agents.

InChI:InChI=1/C7H4BrNO2/c8-4-1-2-6-5(3-4)7(10)9-11-6/h1-3H,(H,9,10)

Upstream product

• 5798-94-7 5-Bromosalicylhydroxamsaeure 
• 21725-69-9 3-hydroxybenzisoxazole 
• 5798-94-7 5-bromo-N,2-dihydroxybenzamide 
• 4068-76-2 5-bromo-2-hydroxy-benzoic acid methyl ester 

Relevant articles and documents

FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS

The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given

Synthesis and biological evaluation of D-amino acid oxidase inhibitors

D-Amino acid oxidase (DAAO) catalyzes the oxidation of D-amino acids including D-serine, a full agonist at the glycine site of the NMDA receptor. A series of benzo[d]isoxazol-3-ol derivatives were synthesized and evaluated as DAAO inhibitors. Among them,

BENZISOXAZOLES

The present invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein m represents an integer from 1 to 3; X represents amino, hydroxy, -oxo or -Z-R1; Y is absent when X represents -Z-R1 and -(C=O)-R66 when X represents oxo; Z represents carbonyl, -oxy-carbonyl- or -NR 55-carbonyl-; R1 represents C1-4alkyl, Ar1, Ar1-C1-4a1ky1-, -NR3R4 or -Het1; R2 represents hydrogen, halo, nitro, hydroxycarbonyl-, C1-4alkyloxy or C1-4alkyl; R33 and R4 are each independently selected from hydrogen, Ar33 or C1-4alkyl; R5 represents hydrogen, C1-4alkylcarbonyl- or Ar4-carbonyl-; R6 represents a substituent selected from the group consisting of C1.4alkyl, Ar55, Ar6-C1-4alkyl- or NR7R8; R7 and R8 are each independently selected from hydrogen, Het4 or C1-4alkyl; Het1 represents a heterocycle selected from oxazolyl, isoxazolyl, imidazolyl or pyrazolyl wherein said heterocycle is optionally substituted with one, two or three substituents selected from the group consisting of amino, C1-4alkyl, hydroxy-C1-4alkyl, phenyl, phenyl-C1-4alkyl- and phenyl substituted with one or more halo substituents; Het4 represents a heterocycle selected from oxazolyl or isoxazolyl, wherein said heterocycle is optionally substituted with one or more substituents selected from the group consisting of amino, C1-4alkyl, hydroxy-C1-4alkyl-, phenyl, phenyl-Cl-4alkyl and phenyl substituted with one or more halo substituents; and Ar1, Ar2, Ar3, Ar4, Ar5 or Ar6 each independently represents phenyl optionally substituted one or where possible two or more substituents selected from halo, nitro, C1-4alkyl, hydroxy or C1-4alkyloxy-.