65697-42-9

Basic information

• Product Name: 1H-Tetrazole, 1-(3-chlorophenyl)-
• CAS NO: 65697-42-9
• Molecular Formula: C7H5ClN4
• Molecular Weight: 180.596
• Mol File: 65697-42-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1H-Tetrazole, 1-(3-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Tetrazole, 1-(3-chlorophenyl)-(65697-42-9)
• EPA Substance Registry System: 1H-Tetrazole, 1-(3-chlorophenyl)-(65697-42-9)

Safety Data

• Hazardous Substances Data: 65697-42-9(Hazardous Substances Data)

Upstream product

• 122-51-0 orthoformic acid triethyl ester 
• 108-42-9 3-chloro-aniline 
• 26060-42-4 N-(3-chlorophenyl)thioformamide 
• 587-04-2 m-Chlorobenzaldehyde 

Downstream Products

• 135220-05-2 [1-(3-Chloro-phenyl)-1H-tetrazol-5-ylmethyl]-dimethyl-amine 
• 1449516-98-6 C₁₅H₁₀BrClN₂ 
• 57039-63-1 6-chloro-2-phenylindole 

Relevant articles and documents

The anchoring of a Cu(ii)-salophen complex on magnetic mesoporous cellulose nanofibers: green synthesis and an investigation of its catalytic role in tetrazole reactions through a facile one-pot route

Today, most synthetic methods are aimed at carrying out reactions under more efficient conditions and the realization of the twelve principles of green chemistry. Due to the importance and widespread applications of tetrazoles in various industries, especially in the field of pharmaceutical chemistry, and the expansion of the use of nanocatalysts in the preparation of valuable chemical reaction products, we decided to use an (Fe3O4@NFC@NSalophCu)CO2H nanocatalyst in this project. In this study, the synthesis of the nanocatalyst (Fe3O4@NFC@NSalophCu)CO2H was explained in a step-by-step manner. Confirmation of the structure was obtained based on FT-IR, EDX, FE-SEM, TEM, XRD, VSM, DLS, TGA, H-NMR, and CHNO analyses. The catalyst was applied to the synthesis of 5-substituted-1H-tetrazole and 1-substituted-1H-tetrazole derivatives through multi-component reactions (MCRs), and the performance was assessed. With advances in science and technology and increasing environmental pollution, the use of reagents and methods that are less dangerous for the environment has received much attention. Therefore, following green chemistry principles, with the help of the (Fe3O4@NFC@NSalophCu)CO2H salen complex as a nanocatalyst that is recyclable, cheap, safe, and available, the use of water as a green solvent, and reduced reaction times, the synthesis of tetrazoles can be achieved.

Ultrasound-promoted one-pot three component synthesis of tetrazoles catalyzed by zinc sulfide nanoparticles as a recyclable heterogeneous catalyst

Ultrasound irradiation was applied for the appropriate and rapid synthesis of 1-substituted tetrazoles through cyclization reaction of various primary amines, sodium azide and triethyl orthoformate. This reaction was effectively catalyzed by ZnS nanoparti

A stereocontrolled 1,2-addition reaction of tetrazoles with alkyl propiolates for the synthesis of highly functionalized enamines

A stereocontrolled 1,2-addition reaction of 1-aryl-1H-tetrazoles with alkyl propiolates for the synthesis of highly functionalized enamines was developed. In the presence of silver oxide (Ag2O), the 1,2-addition reaction generated (Z)-N-cyano enamines in good yields with exclusive formation of the Z-isomers. Meanwhile, the 1,2-addition reaction generated (E)-N-cyano enamines in the presence of Ag2O and potassium carbonate (K2CO 3) with high stereoselectivity and yields. Copyright