657-15-8

Basic information

• Product Name: 3'-NITRO-2,2,2-TRIFLUOROACETOPHENONE
• Synonyms: 3'-NITRO-2,2,2-TRIFLUOROACETOPHENONE;2,2,2-trifluoro-1-(3-nitrophenyl)ethan-1-one;(3-Nitrobenzoyl)trifluoromethane;3'-Nitro-α,α,α-trifluoroacetophenone;α,α,α-Trifluoro-3'-nitroacetophenone;2,2,2-trifluoro-1-(3-nitrophenyl)ethanone;m-Nitro-alpha,alpha,alpha-trifluoroacetophenone;2,2,2-Trifluoro-3'-nitroacetophenone
• CAS NO: 657-15-8
• Molecular Formula: C₈H₄F₃NO₃
• Molecular Weight: 219.12
• EINECS: 211-516-2
• Mol File: 657-15-8.mol
• Article Data: 20

Chemical Properties

• Melting Point: 54.0 to 58.0 °C
• Boiling Point: 113°C/12mmHg(lit.)
• Flash Point: 86.4°C
• Appearance: /
• Density: 1.468g/cm³
• Vapor Pressure: 0.12mmHg at 25°C
• Refractive Index: 1.491
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: soluble in Methanol
• CAS DataBase Reference: 3'-NITRO-2,2,2-TRIFLUOROACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-NITRO-2,2,2-TRIFLUOROACETOPHENONE(657-15-8)
• EPA Substance Registry System: 3'-NITRO-2,2,2-TRIFLUOROACETOPHENONE(657-15-8)

Safety Data

• Hazardous Substances Data: 657-15-8(Hazardous Substances Data)

Usage

General Description

3'-Nitro-2,2,2-trifluoroacetophenone is a chemical compound with the molecular formula C8H6F3NO3. It is a nitro-substituted aromatic ketone that is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 3'-NITRO-2,2,2-TRIFLUOROACETOPHENONE is known for its strong electron-withdrawing properties due to the trifluoromethyl and nitro groups attached to the aromatic ring, making it a valuable building block in organic synthesis. Its unique chemical structure makes it useful in a variety of chemical reactions, including Friedel-Crafts acylation, nucleophilic aromatic substitution, and Suzuki-Miyaura coupling. Additionally, 3'-nitro-2,2,2-trifluoroacetophenone is also utilized in the production of dyes, pigments, and other specialty chemicals.

InChI:InChI=1/C8H4F3NO3/c9-8(10,11)7(13)5-2-1-3-6(4-5)12(14)15/h1-4H

Upstream product

• 434-45-7 2,2,2-Trifluoroacetophenone 
• 110-86-1 pyridine 
• 121-90-4 m-nitrobenzoic acid chloride 
• 110374-85-1 2,2,2-Trifluoro-1-(3-nitro-phenyl)-ethane-1,1-diol 
• 453-77-0 1-(m-nitrophenyl)-2,2,2-trifluoroethyl alcohol 
• 13331-27-6 m-nitrobenzene boronic acid 
• 75072-07-0 S-(trifluoroacetyl)-p-methylthiophenol 
• 1292766-17-6 copper(I) thiophene-2-carboxylate 
• 99-61-6 3-nitro-benzaldehyde 

Downstream Products

• 35462-74-9 1-Nitro-3-(2,2,2-trifluoro-1-trifluoromethyl-ethyl)-benzene 
• 72522-42-0 (S)-2,2,2-Trifluoro-1-(3-nitro-phenyl)-ethanol 
• 453-77-0 1-(m-nitrophenyl)-2,2,2-trifluoroethyl alcohol 
• 1744-19-0 <3-Nitro-phenyl>-trifluormethyl-α-deuterio-carbinol 
• 110374-85-1 2,2,2-Trifluoro-1-(3-nitro-phenyl)-ethane-1,1-diol 
• 220493-46-9 2,2,2-trifluoro-1-(3-nitrophenyl)ethan-1-one oxime 
• 130973-96-5 m-[3-(trifluoromethyl)-3H-1,2-diazirin-3-yl]aniline 
• 629646-13-5 3-(3-nitrophenyl)-3-(trifluoromethyl)-3H-diazirine 
• 629646-12-4 3-(3-nitrophenyl)-3-(trifluoromethyl)diaziridine 
• 629646-11-3 2,2,2-trifluoro-1-(3-nitrophenyl)ethan-1-one O-tosyl oxime 
• 23516-80-5 3-amino-α,α,α-trifluoroacetophenone 
• 1050445-63-0 2-(3-nitrophenyl)-1,1,1-trifluorobutan-2-ol 
• 1200496-74-7 C₁₀H₈F₃NO₂ 
• 1200496-76-9 C₁₈H₁₇F₃N₂O₂ 

Relevant articles and documents

Design, synthesis and evaluation of an NLRP3 inhibitor diazirine photoaffinity probe

The NLRP3 inhibitor MCC950/CRID3 ameliorates a remarkable number of inflammatory disorders in animal models. Herein we describe a trifluoromethyl phenyl diazirine (TPD) photoaffinity probe, called TPD-950-Br, to probe the molecular interactions of MCC950. We show that TPD-950-Br covalently captures proximal species upon photo-activation and inhibits IL-1β production in an NLRP3 inhibitor assay.

Oxidation of α-trifluoromethyl and non-fluorinated alcohols: Via the merger of oxoammonium cations and photoredox catalysis

We present an alcohol oxidation strategy to access α-trifluoromethyl ketones (TFMKs) merging catalytic oxoammonium cation oxidation with visible-light photoredox catalysis. This work uses 4-acetamido-(2,2,6,6-tetramethyl-piperidin-1-yl)oxyl as an organic oxidant capable of generating TFMKs in good yields. The methodology serves as an improvement over previous reports of an analogous oxidation strategy requiring superstoichiometric quantities of oxidant. Both primary and secondary non-fluorinated alcohols can also be oxidised in good yields.

THIENO[3,2-D]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES

Provided are a thieno[3,2-d]pyrimidine derivative of formula (I) or a pharmaceutically acceptable salt thereof having inhibitory activity for protein kinase, and a pharmaceutical composition comprising same for prevention and treatment of abnormal cell growth diseases.