65735-15-1 Usage
General Description
2-Cyano-3-methylpyrazine is a chemical compound present in various types of food, pharmaceuticals, and tobacco. Its molecular formula is C7H7N3, and it belongs to the class of organic compounds known as alkyl-1,2-azoles, which contain a five-member aromatic ring with two carbon atoms and three nitrogen atoms, along with a side chain of an alkyl group. It is used to give a distinct flavor and aroma to processed foods, beverages, and cigarettes. Apart from these, it also holds significance in the pharmaceutical industry due to its potential role in drug synthesis. Its properties include being slightly water-soluble with a faint, nutty odor. Moreover, being a synthetic compound, it is generally considered safe for consumption in controlled amounts.
Check Digit Verification of cas no
The CAS Registry Mumber 65735-15-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,7,3 and 5 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 65735-15:
(7*6)+(6*5)+(5*7)+(4*3)+(3*5)+(2*1)+(1*5)=141
141 % 10 = 1
So 65735-15-1 is a valid CAS Registry Number.
65735-15-1Relevant articles and documents
Studies on Pyrazines. Part 22. Lewis Acid-Mediated Cyanation of Pyrazine N-Oxides with Trimethylsilyl Cyanide: New Route to 2-Substituted 3-Cyanopyrazines
Sato, Nobuhiro,Shimomura, Yuji,Ohwaki, Yoshie,Takeuchi, Ryo
, p. 2877 - 2882 (2007/10/02)
Reaction of 3-substituted pyrazine 1-oxides with trimethylsilyl cyanide in the presence of triethylamine in acetonitrile gave the corresponding cyanopyrazines, yields of which depended remarkably on the substituent.Electron-donating groups enhanced the cyanation with high regioselectivity to 2-substituted 3-cyanopyrazines, while a chloro substituent suppressed the conversion.Addition of zinc halide to the reaction mixture, in most cases, increased the reactivity and improved the regioselectivity.On the other hand, the N-oxides carrying an electron-withdrawing methoxycarbonyl or N-butylcarbamoyl group underwent the cyanation, without need for the Lewis acid, to provide a mixture of nearly equal amounts of 2-substituted 3- and 5-cyanopyrazines.The latter compound was exclusively obtained when 3-methoxycarbonyl- or 3-cyanopyrazine 1-oxide was treated with diethoxyphosphoryl cyanide.
