6575-12-8

Basic information

• Product Name: 2,6-DIBROMOBENZONITRILE
• Synonyms: 2,6-DIBROMOBENZONITRILE
• CAS NO: 6575-12-8
• Molecular Formula: C₇H₃Br₂N
• Molecular Weight: 260.91
• EINECS: 604-604-1
• Mol File: 6575-12-8.mol
• Article Data: 7

Chemical Properties

• Melting Point: 208-209 °C
• Boiling Point: 326.5°C at 760 mmHg
• Flash Point: 151.3°C
• Appearance: /
• Density: 2.06g/cm³
• Vapor Pressure: 0.000214mmHg at 25°C
• Refractive Index: 1.662
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2,6-DIBROMOBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DIBROMOBENZONITRILE(6575-12-8)
• EPA Substance Registry System: 2,6-DIBROMOBENZONITRILE(6575-12-8)

Safety Data

• Hazardous Substances Data: 6575-12-8(Hazardous Substances Data)

Usage

General Description

2,6-Dibromobenzonitrile is a chemical compound with the molecular formula C7H3Br2N. It is a white crystalline solid that is insoluble in water but soluble in organic solvents. 2,6-Dibromobenzonitrile is used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and materials. It is also used as an intermediate in the production of dyes and other industrial products. The compound is known to be toxic to aquatic organisms and may cause long-term adverse effects in the environment. It is important to handle and dispose of 2,6-Dibromobenzonitrile with care and in accordance with safety guidelines.

InChI:InChI=1/C7H3Br2N/c8-6-2-1-3-7(9)5(6)4-10/h1-3H

Upstream product

• 608-30-0 2,6-dibromoaniline 
• 100-47-0 benzonitrile 
• 544-92-3 copper(I) cyanide 
• 151-50-8 potassium cyanide 
• 13402-32-9 1,3-dibromo-2-nitrobenzene 
• 89692-43-3 C₇H₅Br₂NO 
• 10442-39-4 tetra-n-butylammonium cyanide 
• 1897-52-5 2,6 difluorobenzonitrile 
• 77326-36-4 2-amino-6-fluorobenzonitrile 
• 79544-27-7 2-bromo-6-fluorobenzonitrile 
• 77326-62-6 2-amino-6-bromobenzonitrile 

Downstream Products

• 601-84-3 2,6-dibromobenzoic acid 
• 96237-91-1 2,6-dibromobenzamide 
• 59870-37-0 2,6-dibromobenzoyl chloride 
• 96237-99-9 1-(2,6-dibromobenzoyl)-2-(p-nitrobenzoyl)hydrazine 
• 1039766-04-5 C₁₄H₁₁Br₂ClN₂ 
• 1039766-16-9 C₁₃H₁₆Br₂N₂ 
• 1039765-55-3 C₁₈H₂₀Br₂N₂ 

Relevant articles and documents

Preparation method of 2,6-dibromoaniline

The invention discloses a preparation method of 2,6-dibromoaniline. According to the method, 2,6-difluorobenzonitrile is used as an initial raw material, and the 2,6-dibromoaniline is synthesized through six steps of reactions including ammonolysis, diazotization bromination, re-ammonolysis, re-diazotization bromination, amidation and Hofmann degradation. The 2,6-dibromoaniline obtained in the process is a brown solid, and the purity of the 2,6-dibromoaniline is 98% or above.

Copper-free Sandmeyer cyanation of arenediazonium o-benzenedisulfonimides

Arene and heteroarenediazonium o-benzenedisulfonimides can be used as efficient reagents in Sandmeyer cyanation. This work reports such reactions carried out by us under very mild conditions using tetrabutyl ammonium cyanide as a safe cyanide source and, interestingly, without the need for a Cu catalyst. The reactions have given rise to aryl nitriles in good yields (25 examples, average yield 75%). A good amount of o-benzenedisulfonimide was recovered from each reaction and then reused to prepare other salts. Mechanistic insights have allowed us to highlight the fundamental role of the o-benzenedisulfonimide anion as an electron transfer agent.

N-Substituted Glycine Derivatives: Prolyl Hydroxylase Inhibitors

The invention described herein relates to certain pyrimidinedione N-substituted glycine derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.