65845-73-0Relevant articles and documents
A Metal-Free Approach for Bronsted Acid Promoted C-H Alkylation of Heteroarenes with Alkyl Peroxides
Zeng, Yuehua,Qian, Bo,Li, Yajun,Bao, Hongli
, p. 3250 - 3256 (2018/06/08)
A metal-free protocol for Minisci C-H alkylation of heteroarenes using alkyl peroxides as the alkylating reagents and internal oxidants simultaneously under promotion of Bronsted acid has been demonstrated. A series of alkyl substituted heteroarenes were readily prepared by the C-H alkylation in moderate to good yields. A possible pathway involving the addition of alkyl radical to heterocycle followed by rearomatization is described.