65846-46-0

Basic information

• Product Name: Pyridine, 2-(5-phenyl-2-oxazolyl)-
• CAS NO: 65846-46-0
• Molecular Formula: C14H10N2O
• Molecular Weight: 222.246
• Mol File: 65846-46-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Pyridine, 2-(5-phenyl-2-oxazolyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2-(5-phenyl-2-oxazolyl)-(65846-46-0)
• EPA Substance Registry System: Pyridine, 2-(5-phenyl-2-oxazolyl)-(65846-46-0)

Safety Data

• Hazardous Substances Data: 65846-46-0(Hazardous Substances Data)

Upstream product

• 62218-63-7 2-(5-phenyl-isoxazol-3-yl)-pyridine 
• 86119-84-8 phosphoric acid 
• 108-24-7 acetic anhydride 
• 1816-88-2 2-azido-1-phenylethan-1-one 
• 70-11-1 α-bromoacetophenone 
• 29745-44-6 pyridine-2-carbonyl chloride 
• 5468-37-1 2-aminoacetophenone hydrochloride 
• 109-09-1 2-chloropyridine 
• 1006-68-4 5-phenyloxazole 
• 199477-91-3 N-(2-phenylethyl)pyridine-2-carboxamide 
• 694-59-7 pyridine N-oxide 

Relevant articles and documents

Iodine catalysed intramolecular C(sp3)-H functionalization: synthesis of 2,5-disubstituted oxazoles from N-arylethylamides

Iodine catalyzed synthesis of 2,5-disubstituted oxazoles from N-arylethylamides through intramolecular C(sp3)-H functionalization under metal-free conditions is described. The method is tolerable to a wide range of substrates having a variety of functional groups with moderate to good yields of the products.

Direct C-H bond arylation of (benzo)oxazoles with aryl chlorides catalyzed by N-heterocyclic carbene-palladium(II)-1-methylimidazole complex

The direct C-H bond arylation of (benzo)oxazoles with aryl chlorides was achieved catalyzed by a well-defined NHC-Pd(II)-Im complex. Under the optimal conditions, various aryl chlorides were successfully applied as the arylating reagents to achieve the 2-aryl (benzo)oxazoles in acceptable to high yields, providing a convenient and alternative method for the direct C-H bond arylation of (benzo)oxazoles and enriching the chemistry of the NHC-Pd(II) complex in organic synthesis.

A New Versatile Synthesis of Oxazoles by Intramolecular Aza-Wittig Reaction

A new synthesis of oxazoles by an intramolecular aza-Wittig reaction is described.Readily available α-azido ketones 2 were converted to (Z)-β-(acyloxy)vinyl azides 3 by selective enol acylation.These vinyl azides 3 reacted with triethyl phosphite to afford the corresponding oxazole derivatives 5 via the Staudinger reaction, followed by an intramolecular aza-Wittig reaction.In particular, this oxazole synthesis was useful for oxazoles having acid-labile substituents.