65849-33-4

Basic information

• Product Name: Phenol, 2-bromo-4-methyl-, benzoate
• CAS NO: 65849-33-4
• Molecular Formula: C14H11BrO2
• Molecular Weight: 291.144
• Mol File: 65849-33-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Phenol, 2-bromo-4-methyl-, benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 2-bromo-4-methyl-, benzoate(65849-33-4)
• EPA Substance Registry System: Phenol, 2-bromo-4-methyl-, benzoate(65849-33-4)

Safety Data

• Hazardous Substances Data: 65849-33-4(Hazardous Substances Data)

Upstream product

• 614-34-6 p-cresyl benzoate 
• 6627-55-0 2-bromo-p-cresol 
• 98-88-4 benzoyl chloride 
• 7726-95-6 bromine 
• 7553-56-2 iodine 
• 127-09-3 sodium acetate 
• 7789-69-7 phosphorus pentabromide 
• 64-19-7 acetic acid 

Downstream Products

• 614-34-6 p-cresyl benzoate 
• 536974-78-4 benzoic acid 2-bromo-4-{[(4-cyanophenyl)[1,2,4]triazol-4-ylamino]methyl}phenyl ester 
• 537674-84-3 4-[(3-Bromo-4-hydroxybenzyl)(4-cyanophenyl)amino]-4H-[1,2,4]triazole 
• 536974-77-3 3-bromo-4-benzoyloxybenzyl bromide 
• 1470-57-1 2-hydroxy-5-methylbenzophenone 
• 65-85-0 benzoic acid 
• 6627-55-0 2-bromo-p-cresol 

Relevant articles and documents

Dual aromatase-steroid sulfatase inhibitors

By introducting the steroid sulfatase inhibitory pharmacophore into aromatase inhibitor 1 (YM511), two series of single agent dual aromatase-sulfatase inhibitors (DASIs) were generated. The best DASIs in'vitro (JEG-3 cells) are 5, (IC50(aromatase) = 0.82 nM; IC 50(sulfatase) = 39 nM), and 14, (IC50(aromatase) = 0.77 nM; IC50(sulfatase) = 590 nM). X-ray crystallography of 5, and docking studies of selected compounds into an aromatase homology model and the steroid sulfatase crystal structure are presented. Both 5 and 14 inhibit aromatase and sulfatase in PMSG pretreated adult female Wistar rats potently 3 h after a single oral 10 mg/kg dose. Almost complete dual inhibition is observed for 5 but the levels were reduced to 85% (aromatase) and 72% (sulfatase) after 24 h. DASI 5 did not inhibit aldosterone synthesis. The development of a potent and selective DASI should allow the therapeutic potential of dual aromatase-sulfatase inhibition in hormone-dependent breast cancer to be assessed.

Carbanionically Induced -Migrations of ?- and Coordinatively Unsaturated Groups

According to a general reaction scheme, o-lithioaryl esters 4a,b, amides 13a,b 17b, and amidines 39b of non-enolizable carboxylic acids as well as a corresponding diphenylphosphinic amide 51b react under mild conditions to give the intensely coloured lithium derivatives of o-acylphenoles 6a,b and o-acylarenamines 15a,b, 18a, 41a, 52a, which are finally hydrolyzed to the neutral products 7a,b, 14a,b, 18b, 41b, 52b, respectively.The lithiated precursors of the rearrangement are mostly prepared by halogen/metal exchange reactions.In the case of N,N-di-p-tolylpivalamide 33 such a -rearrangement also could be induced by direct metalation of the educt.With N-methyl-N-phenylpivalamide (29), however, exclusive metalation of the N-methyl group occurs, followed by -migration of the pivaloyl group.Silyl groups, too, can undergo analogous -shifts, as was demonstrated by the rearrangement of the o-lithiated N-(trimethylsilyl)aniline 63b to the o-(trimethylsilyl)anilines 65a,b.When a benzoyl and sulfonyl group can compete for the -shifts, as in the N-tosylated benzamide 47b, only the benzoyl group migrates.However, the migration tendency of the trimethylsilyl group equals that of the benzoyl group as was shown with the N-silylated benzamide 66b.