658710-29-3Relevant articles and documents
Nitro and amino substitution within the A-ring of 5H-8,9-dimethoxy-5-(2-N, N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: Influence on topoisomerase I-targeting activity and cytotoxicity
Ruchelman, Alexander L.,Kerrigan, John E.,Li, Tsai-Kun,Zhou, Nai,Liu, Angela,Liu, Leroy F.,LaVoie, Edmond J.
, p. 3731 - 3742 (2007/10/03)
Recently, 5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)-2,3- methylenedioxydibenzo[c,h][1,6]naphthyridin-6-one, 1, was identified as a TOP1-targeting agent with pronounced antitumor activity. In the present study, the effect on activity of substituting a
Synthesis and functional activity of (2-aryl-1-piperazinyl)-N-(3- methylphenyl)acetamides: Selective dopamine D4 receptor agonists
Matulenko, Mark A.,Hakeem, Ahmed A.,Kolasa, Teodozyi,Nakane, Masaki,Terranova, Marc A.,Uchic, Marie E.,Miller, Loan N.,Chang, Renjie,Donnelly-Roberts, Diana L.,Namovic, Marian T.,Moreland, Robert B.,Brioni, Jorge D.,Stewart, Andrew O.
, p. 3471 - 3483 (2007/10/03)
Diaryl piperazine acetamides were identified as potent and selective dopamine D4 receptor agonists. Our strategy is based on an amide bond reversal of an acid sensitive, dopamine D4 receptor partial agonist, PD 168077. This reversal provided compounds with excellent potency and improved stability. Systematic evaluation of the substitution on the aryl piperazine portion revealed a significant effect on functional activity. The synthesis and biological activity of these new dopamine D4 agonists is discussed.
