65938-77-4 Usage
Description
5-METHYLPYRIDINE-2-SULFONAMIDE, also known as 5-Methyl-2-pyridinesulfonamide, is an arylsulfonamide compound with the molecular formula C6H8N2O2S. It is a synthetic organic compound that serves as a crucial intermediate in the pharmaceutical industry due to its unique chemical properties and reactivity.
Uses
Used in Pharmaceutical Industry:
5-METHYLPYRIDINE-2-SULFONAMIDE is used as an intermediate in the preparation of the endothelin receptor antagonist, Clazosentan. This application is significant because Clazosentan is a medication used to treat patients with subarachnoid hemorrhage, a life-threatening condition that occurs when blood flows over the surface of the brain.
Used in Chemical Synthesis:
5-METHYLPYRIDINE-2-SULFONAMIDE is also used as a reagent in the preparation of aziridines through copper or iron-catalyzed aziridination. Aziridines are valuable compounds in organic chemistry, as they serve as building blocks for the synthesis of various pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Research and Development:
5-METHYLPYRIDINE-2-SULFONAMIDE has been utilized in the development of a copper-catalyzed aziridination protocol, which is an important advancement in the field of chemical synthesis. This protocol allows for the efficient and selective formation of aziridines, which are essential in the synthesis of complex molecules and biologically active compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 65938-77-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,9,3 and 8 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 65938-77:
(7*6)+(6*5)+(5*9)+(4*3)+(3*8)+(2*7)+(1*7)=174
174 % 10 = 4
So 65938-77-4 is a valid CAS Registry Number.
InChI:InChI=1/C6H8N2O2S/c1-5-2-3-6(8-4-5)11(7,9)10/h2-4H,1H3,(H2,7,9,10)
65938-77-4Relevant articles and documents
Butyne diol derivatives
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, (2008/06/13)
The present invention relates to novel butyne diol derivatives of the general formula I and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more compounds of the general formula I and especially their use as endothelin receptor antagonists.
