659726-98-4Relevant articles and documents
Amino substituted analogs of 1-phenyl-3-phenylimino-2-indolones with potent galanin Gal3 receptor binding affinity and improved solubility
Konkel, Michael J.,Packiarajan, Mathivanan,Chen, Heidi,Topiwala, Upendra P.,Jimenez, Hermogenes,Talisman, Ian Jamie,Coate, Heather,Walker, Mary W.
, p. 3950 - 3954 (2006)
A series of amino analogs of 1,3-dihydro-1-phenyl-3-[[3-(trifluoromethyl)phenyl]imino]-2H-indol-2-one (1) were synthesized to improve aqueous solubility, while retaining high affinity for the human galanin Gal3 receptor. A very potent analog (9
3-Imino-2-indolones for the treatement of depression and/or anxiety
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Page 16, (2010/02/06)
This invention is directed to indolone derivatives which are selective antagonists for the GalR3 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutica