659746-56-2Relevant articles and documents
A Facile Synthesis of AICAR from Inosine
Kohyama, Naoki,Yamamoto, Yukio
, p. 2639 - 2642 (2007/10/03)
5-Amino-1-β-D-ribofuranosylimidazole-4-carboxamide (AICAR; 1) (Figure 1) was efficiently prepared from inosine through its 1-alkoxymethylderivatives. The stability of these derivatives enabled their purification by column chromatography (silica gel). The operation ensured the high quality of 1, which was obtained in good yield through alkaline hydrolysis of the derivatives.