6604-46-2

Basic information

• Product Name: 5-chloro-N²-phenylpyridine-2,3-diamine
• Synonyms: 5-chloro-N²-phenylpyridine-2,3-diamine
• CAS NO: 6604-46-2
• Molecular Weight: 219.673
• Mol File: 6604-46-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-chloro-N²-phenylpyridine-2,3-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-N²-phenylpyridine-2,3-diamine(6604-46-2)
• EPA Substance Registry System: 5-chloro-N²-phenylpyridine-2,3-diamine(6604-46-2)

Safety Data

• Hazardous Substances Data: 6604-46-2(Hazardous Substances Data)

Upstream product

• 3493-98-9 5-chloro-3-nitro-N-phenylpyridin-2-amine 
• 62-53-3 aniline 
• 21427-62-3 2,5-dichloro-3-nitropyridine 
• 78607-32-6 3-amino-2,5-dichloropyridine 

Relevant articles and documents

A Scaffold-Hopping Strategy toward the Identification of Inhibitors of Cyclin G Associated Kinase

We recently reported the discovery of isothiazolo[4,3-b]pyridine-based inhibitors of cyclin G associated kinase (GAK) displaying low nanomolar binding affinity for GAK and demonstrating broad-spectrum antiviral activity. To come up with novel core structures that act as GAK inhibitors, a scaffold-hopping approach was applied starting from two different isothiazolo[4,3-b]pyridines. In total, 13 novel 5,6- and 6,6-fused bicyclic heteroaromatic scaffolds were synthesized. Four of them displayed GAK affinity with Kd values in the low micromolar range that can serve as chemical starting points for the discovery of GAK inhibitors based on a different scaffold.