660431-66-3

Basic information

• Product Name: α-Tosyl-(2,4-difluorobenzyl)isocyanide
• Synonyms: α-Tosyl-(2,4-difluorobenzyl)isocyanide;a-Tosyl-(2,4-difluorobenzyl)isocyanide;2,4-Difluoro-1-(isocyano(tosyl)methyl)benzene;2,4-Difluoro-1-[isocyano-(toluene-4-sulfonyl)-methyl]-benzene;2,4-difluoro-1-[isocyano[(4-methylphenyl)sulfonyl]methyl]benzene
• CAS NO: 660431-66-3
• Molecular Formula: C₁₅H₁₁F₂NO₂S
• Molecular Weight: 307.319
• Mol File: 660431-66-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: α-Tosyl-(2,4-difluorobenzyl)isocyanide(CAS DataBase Reference)
• NIST Chemistry Reference: α-Tosyl-(2,4-difluorobenzyl)isocyanide(660431-66-3)
• EPA Substance Registry System: α-Tosyl-(2,4-difluorobenzyl)isocyanide(660431-66-3)

Safety Data

• Hazardous Substances Data: 660431-66-3(Hazardous Substances Data)

Usage

General Description

α-Tosyl-(2,4-difluorobenzyl) isocyanide is a chemical compound that contains the tosyl group, a difluorobenzyl group, and an isocyanide group. It is commonly used in organic synthesis as a versatile building block for the preparation of various organic compounds. α-Tosyl-(2,4-difluorobenzyl)isocyanide has been reported to be an effective reagent for the synthesis of various heterocycles and can be used in the preparation of pharmaceuticals and agrochemicals. It is important to handle this compound with care, as isocyanides are known to be toxic and can pose a risk to human health.

Upstream product

• 668990-82-7 N-[(2.4-difluoro-phenyl)-(toluene-4-sulfonyl)-methyl]-formamide 
• 536-57-2 p-toluene sulfinic acid 
• 1550-35-2 2,4-difluorobenzaldehyde 

Downstream Products

• 1902955-29-6 methyl 5-(2,4-difluorophenyl)-4-methoxy-1H-pyrrole-3-carboxylate 

Relevant articles and documents

A 4 - methoxy pyrrole intermediate preparation method

The present invention provides 4 - methoxy pyrrole intermediate preparation method, comprises the following steps: (1) of formula (I) compound 2, 4 - difluorobenzaldehyde with formula (II) compound to the [...] sulfonic acid in the alkaline solvent and th

DI AND TRIFLUORO-TRIAZOLO-PYRIDINES ANTI-INFLAMMATORY COMPOUNDS

The present invention relates to novel triazolo-pyridines of the formula (I) wherein R1 is fluoro; s is an integer from two to three; R2 is (C3-C6)cycloalkyl optionally substituted by one or two moieties independently selected from the group consisting of halo, (Cl-C4)alkyl, hydroxy, (Cl-C6)alkoxy and (C1-C6)alkyl-(C=O)-0-; or R2 is (Cl-C6)alkyl optionally substituted by one or two moieties independently selected from the group consisting of halo, (C1-C6)alkyl, hydroxy, (C1-C6)alkoxy and (C1-C6)alkyl-(C=O)-0-; with the proviso that said compound of formula (I) cannot be 6-[4-(2,4-Difluoro-phenyl)-oxazol-5-yl]-3-isopropyl-[1,2,4]triazolo[4,3-a]pyridine; or 6-[4-(3,4-Difluoro-phenyl)-oxazol-5-yl]-3-isopropyl-[1,2,4]triazolo[4,3-a]pyridine; to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the present invention are potent inhibitors of MAP kinases, preferably p38 kinase. They are useful in the treatment of inflammation, osteoarthritis, rheumatoid arthritis, cancer, repurfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.