66045-03-2

Basic information

• Product Name: Benzenepropanamide, a-hydroxy-b-oxo-N-phenyl-
• CAS NO: 66045-03-2
• Molecular Formula: C15H13NO3
• Molecular Weight: 255.273
• Mol File: 66045-03-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzenepropanamide, a-hydroxy-b-oxo-N-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanamide, a-hydroxy-b-oxo-N-phenyl-(66045-03-2)
• EPA Substance Registry System: Benzenepropanamide, a-hydroxy-b-oxo-N-phenyl-(66045-03-2)

Safety Data

• Hazardous Substances Data: 66045-03-2(Hazardous Substances Data)

Upstream product

• 959-66-0 3-oxo-3-phenylpropionanilide 
• 62-53-3 aniline 
• 614-20-0 3-oxo-3-phenylpropionic acid 

Downstream Products

• 129-24-8 4-phenyl-3-hydroxyquinolin-2(1H)-one 

Relevant articles and documents

One-pot synthesis of 3-hydroxyquinolin-2(1 H)-ones from N-phenylacetoacetamide via PhI(OCOCF3)2-mediated α-hydroxylation and H2SO4-promoted intramolecular cyclization

A clean, one-pot synthesis of the biologically important 3-hydroxyquinolin-2(1H)-one compounds has been realized from the readily available N-phenylacetoacetamide derivatives through a PhI(OCOCF 3)2-mediated α-hydroxylation and a H 2SO4-promoted intramolecular condensation. The hydroxyl group in the generated α-hydroxylated intermediate can be well tolerated in the second H2SO4-promoted cyclization step.