66050-00-8

Basic information

• Product Name: 2-benzylhexahydro-1H-isoindole-1,3(2H)-dione
• Synonyms: 2-benzylhexahydro-1H-isoindole-1,3(2H)-dione
• CAS NO: 66050-00-8
• Molecular Weight: 243.305
• Mol File: 66050-00-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-benzylhexahydro-1H-isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-benzylhexahydro-1H-isoindole-1,3(2H)-dione(66050-00-8)
• EPA Substance Registry System: 2-benzylhexahydro-1H-isoindole-1,3(2H)-dione(66050-00-8)

Safety Data

• Hazardous Substances Data: 66050-00-8(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 13149-00-3 1,2-cis-cyclohexanedicarboxylic anhydride 
• 15753-50-1 cis-1,2-cyclohexanedimethanol 
• 622-79-7 benzyl azide 
• 100-39-0 benzyl bromide 
• 7506-66-3 cis-hexahydrophthalimide 
• 610-09-3 (1R,2S)-cyclohexane-1,2-dicarboxylic acid 
• 331986-99-3 (1R,2S)-2-Benzylcarbamoyl-cyclohexanecarboxylic acid 

Downstream Products

• 85738-35-8 N-benzyl-9-isobutylidene-cis-8-azabicyclo<4.3.0>nonan-7-one 
• 85738-36-9 N-benzyl-9-isobutyl-8-azabicyclo<4.3.0>non-1(6)-en-7-one 
• 80818-40-2 cis-N-benzyl-9-hydroxy-8-azabicyclo<4.3.0>nonan-7-one 
• 255914-99-9 2-benzyl-3-hydroxy-octahydroisoindol-1-one 
• 80818-48-0 N-benzyl-cis-8-azabicyclo<4.3.0>nonan-7-one 
• 80818-48-0 N-benzyl-trans-8-azabicyclo<4.3.0>nonan-7-one 
• 80818-41-3 N-benzyl-8-azabicyclo<4.3.0>non-1(6)-en-7-one 
• 85738-33-6 (1RS, 6SR, 9RS)-N-benzyl-9-isobutyl-trans-8-azabicyclo<4.3.0>nonan-7-one 
• 65376-02-5 (1S,6R)-8-oxabicyclo[4.3.0]nonan-7-one 
• 89395-29-9 (3aR,7aS)-hexahydroisobenzofuran-1-one 

Relevant articles and documents

Chiral bases as useful probes of lithium amide reactivity

Experiments involving competition between chiral and achiral lithium amides provide a qualitative impression of the kinetics of different amide motifs in enolization reactions. The level of enantioselectivity was not diminished by the inclusion of lithium

Titanium- And Lewis acid-mediated cyclopropanation of imides

We report a straightforward synthesis of 1-azaspirocyclopropane lactams from imides. Following the described procedure, polycyclic nitrogen heterocycles containing a cyclopropane unit could be obtained from unsaturated imides.

Oxazaborolidine catalysed enantioselective reduction of cyclic meso-imides

Full details of the enantioselective reduction of cyclic meso-imides catalysed by an enantiopure oxazaborolidine derived from (S)-α,α-diphenylprolinol are reported. Treatment of the imides with borane in the presence of the catalyst led to a mixture of cis- and trans-hydroxylactams and, after subsequent ethanolysis, to the corresponding diastereomerically pure trans-ethoxylactams. The enantiomeric excesses were shown to be 68-94% by HPLC-determination. One example, in which the ethoxylactam was converted into the benzenesulfonyllactam, could be crystallized to >99% enantiomeric purity.