66134-18-7Relevant articles and documents
Bimetallic Au-Pd nanochain networks: Facile synthesis and promising application in biaryl synthesis
Wang, Zheng-Jun,Wang, Xia,Lv, Jing-Jing,Feng, Jiu-Ju,Xu, Xinhua,Wang, Ai-Jun,Liang, Zhiwu
, p. 3894 - 3899 (2017/07/12)
A simple and facile method is described for the morphology-controlled synthesis of bimetallic Au-Pd alloyed nanochain networks (NNCs) that show high catalytic performance for the Ullmann intermolecular homocoupling of aromatic or alkyl halides (X = I, Br, Cl) in aqueous media and can be reused at least five times, which can also be applied to intramolecular homocoupling.
Structure-activity relationship studies of indole-based compounds as small molecule HIV-1 fusion inhibitors targeting glycoprotein 41
Zhou, Guangyan,Sofiyev, Vladimir,Kaur, Hardeep,Snyder, Beth A.,Mankowski, Marie K.,Hogan, Priscilla A.,Ptak, Roger G.,Gochin, Miriam
supporting information, p. 5270 - 5281 (2014/07/08)
We previously described indole-containing compounds with the potential to inhibit HIV-1 fusion by targeting the hydrophobic pocket of transmembrane glycoprotein gp41. Here we report optimization and structure-activity relationship studies on the basic scaffold, defining the role of shape, contact surface area, and molecular properties. Thirty new compounds were evaluated in binding, cell-cell fusion, and viral replication assays. Below a 1 μM threshold, correlation between binding and biological activity was diminished, indicating an amphipathic requirement for activity in cells. The most active inhibitor 6j exhibited 0.6 μM binding affinity and 0.2 μM EC50 against cell-cell fusion and live virus replication and was active against T20 resistant strains. Twenty-two compounds with the same connectivity displayed a consensus pose in docking calculations, with rank order matching the biological activity. The work provides insight into requirements for small molecule inhibition of HIV-1 fusion and demonstrates a potent low molecular weight fusion inhibitor.
Benzotriazol-1-ylmethanol: An excellent bidentate ligand for the copper/palladium-catalyzed C-N and C-C coupling reaction
Jha, Rajeev R.,Singh, Jaspal,Tiwari, Rakesh K.,Verma, Akhilesh K.
, p. 228 - 248 (2013/02/23)
An efficient benzotriazole based N,O bidentate ligands for the Cu-catalyzed N-arylation of π-excessive nitrogen heterocycles is described. This ligand accomplishes C-N coupling of Nheterocycles and C-C coupling of boronic acids with a variety of hindered, functionalized aryl/heteroaryl halides under mild reaction conditions in good to excellent yields. Using his ligand C-N and C-C (Suzuki) couplings with bromoarenes could be conducted with less catalyst loading. A wide array of deactivated and hindered aryl halides react cleanly to afford the functionalized biaryl derivatives in high yields. ARKAT-USA, Inc.
