66202-86-6 Usage
Description
METHYL 2-(2-FLUORO-BIPHENYL-4YL)PROPIONATE, also known as Methyl Flurbiprofen, is a prodrug of flurbiprofen, which is an anti-inflammatory agent used as an analgesic. It is a white solid with chemical properties that make it suitable for pharmaceutical applications.
Uses
Used in Pharmaceutical Industry:
METHYL 2-(2-FLUORO-BIPHENYL-4YL)PROPIONATE is used as an intermediate for the synthesis of the metabolite of Flurbiprofen for its anti-inflammatory and analgesic properties. It serves as a crucial component in the development of medications aimed at reducing inflammation and alleviating pain.
Used in Anti-inflammatory Applications:
METHYL 2-(2-FLUORO-BIPHENYL-4YL)PROPIONATE is used as an active ingredient in anti-inflammatory medications, specifically for its ability to reduce inflammation and provide pain relief. Its role in the synthesis of flurbiprofen makes it an essential component in the treatment of various inflammatory conditions.
Used in Analgesic Applications:
METHYL 2-(2-FLUORO-BIPHENYL-4YL)PROPIONATE is used as a key component in the development of analgesic medications, targeting the relief of pain and discomfort. Its conversion to flurbiprofen allows for the creation of effective pain management solutions.
Check Digit Verification of cas no
The CAS Registry Mumber 66202-86-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,2,0 and 2 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 66202-86:
(7*6)+(6*6)+(5*2)+(4*0)+(3*2)+(2*8)+(1*6)=116
116 % 10 = 6
So 66202-86-6 is a valid CAS Registry Number.
InChI:InChI=1/C16H15FO2/c1-11(16(18)19-2)13-8-9-14(15(17)10-13)12-6-4-3-5-7-12/h3-11H,1-2H3
66202-86-6Relevant articles and documents
Suzuki-Miyaura coupling of aryl carbamates, carbonates, and sulfamates
Quasdorf, Kyle W.,Riener, Michelle,Petrova, Krastina V.,Garg, Neil K.
supporting information; experimental part, p. 17748 - 17749 (2010/04/01)
(Chemical Equation Presented) The first Suzuki-Miyaura cross-couplings of carbamates, carbonates, and sulfamates is described. The method provides a powerful means of using simple derivatives of phenol as precursors to polysubstituted aromatic compounds, as exemplified by a concise synthesis of the anti-inflammatory drug flurbiprofen.
ESTERS OF ARYLPROPIONIC ACIDS WITH 1,2:5,6-DI-O-ISOPROPYLIDENE- AND 1,2-O-ISOPROLYLIDENE-α-D-GLUCOFURANOSE
Svoboda, Jiri,Capek, Karel,Palecek, Jaroslav
, p. 766 - 774 (2007/10/02)
On fractional crystallization of 3-O-(2-(2-fluoro-4-biphenylyl)propionyl-, 3-O-(2-(4-isobutylphenyl)propionyl)- and 3-O-(2-(6-methoxy-2-naphthyl)propionyl)-1,2:5,6-di-O-isopropylidene-α-D-glucofuranoses V - VII optically pure R-diastereoisomers were isolated.The derivatives of 1,2-O-isopropylidene-α-D-glucofuranose obtained on partial deacetylation of esters V - VII were separated chromatographically to R and S-diastereoisomers.Their hydrolysis or transesterification afforded optically pure arylpropionic acids or their methyl esters, respectively.Kinetic resolutionof the acids gives rise to esters V - VII enriched in R-diastereoisomer.
