662138-60-5

Basic information

• Product Name: ETHYL(2,5-DIFLUOROPHENYL)ACETATE
• Synonyms: ETHYL(2,5-DIFLUOROPHENYL)ACETATE;(2,5-Difluorophenyl)acetic acid ethyl ester
• CAS NO: 662138-60-5
• Molecular Formula: C₁₀H₁₀F₂O₂
• Molecular Weight: 200.1820064
• Product Categories: Phenyls & Phenyl-Het;Esters;Phenyls & Phenyl-Het
• Mol File: 662138-60-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 224.4±25.0 °C(Predicted)
• Appearance: /
• Density: 1 +-.0.06 g/cm3(Predicted)
• CAS DataBase Reference: ETHYL(2,5-DIFLUOROPHENYL)ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL(2,5-DIFLUOROPHENYL)ACETATE(662138-60-5)
• EPA Substance Registry System: ETHYL(2,5-DIFLUOROPHENYL)ACETATE(662138-60-5)

Safety Data

• Hazardous Substances Data: 662138-60-5(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 85068-27-5 2,5-difluorophenylacetic acid 

Downstream Products

• 151954-42-6 ethyl α-bromo-2,5-difluorophenylacetate 
• 151954-49-3 3-<<4-phenyl>methyl>-5,7-dimethyl-2-ethyl-3H-imidazo<4,5-b>pyridine 
• 151954-59-5 3-<<4-phenyl>methyl>-5,7-dimethyl-2-ethyl-3H-imidazo<4,5-b>pyridine 
• 151954-62-0 3-<<4-phenyl>methyl>-5,7-dimethyl-2-ethyl-3H-imidazo<4,5-b>pyridine 
• 151954-64-2 3-<<4-phenyl>methyl>-5,7-dimethyl-2-ethyl-3H-imidazo<4,5-b>pyridine 
• 862255-56-9 2-(2,5-difluorophenyl)ethanol 
• 109346-82-9 2-(2,5-difluorophenyl)acetaldehyde 

Relevant articles and documents

2-(Halogenated Phenyl) acetamides and propanamides as potent TRPV1 antagonists

A series consisting of 117 2-(halogenated phenyl) acetamide and propanamide analogs were investigated as TRPV1 antagonists. The structure–activity analysis targeting their three pharmacophoric regions indicated that halogenated phenyl A-region analogs exhibited a broad functional profile ranging from agonism to antagonism. Among the compounds, antagonists 28 and 92 exhibited potent antagonism toward capsaicin for hTRPV1 with Ki[CAP] = 2.6 and 6.9 nM, respectively. Further, antagonist 92 displayed promising analgesic activity in vivo in both phases of the formalin mouse pain model. A molecular modeling study of 92 indicated that the two fluoro groups in the A-region made hydrophobic interactions with the receptor.

PYRROLIDINE INHIBITORS OF IAP

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