662149-13-5

Basic information

• Product Name: 4-Hydroxy Duloxetine
• Synonyms: 4-[(1S)-3-(Methylamino)-1-(2-thienyl)propoxy]-1-naphthaleno;4-Hydroxy Duloxetine;4-[(1S)-3-(Methylamino)-1-(2-thienyl)propoxy]-1-naphthalenol
• CAS NO: 662149-13-5
• Molecular Formula: C18H19NO2S
• Molecular Weight: 313.419
• Product Categories: Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Chiral Reagents;Sulfur & Selenium Compounds
• Mol File: 662149-13-5.mol
• Article Data: 0

Chemical Properties

• Melting Point: 140-143°C
• Boiling Point: 516.6°C at 760 mmHg
• Flash Point: 266.2°C
• Appearance: /
• Density: 1.227g/cm³
• Vapor Pressure: 2.72E-11mmHg at 25°C
• Refractive Index: 1.649
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly), Methanol (Very Slightly, Heated)
• PKA: 9.97±0.40(Predicted)
• CAS DataBase Reference: 4-Hydroxy Duloxetine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxy Duloxetine(662149-13-5)
• EPA Substance Registry System: 4-Hydroxy Duloxetine(662149-13-5)

Safety Data

• Hazardous Substances Data: 662149-13-5(Hazardous Substances Data)

Usage

Description

4-Hydroxy Duloxetine, also known as a major metabolite of Duloxetine, is a tan solid with unique chemical properties. It is derived from the parent compound Duloxetine, which is a widely used medication for various conditions. The presence of a hydroxyl group in its structure distinguishes it from the parent compound and may contribute to its potential applications in different fields.

Uses

Used in Pharmaceutical Industry:
4-Hydroxy Duloxetine is used as an active pharmaceutical ingredient (API) for its potential therapeutic effects. As a metabolite of Duloxetine, it may exhibit similar or enhanced pharmacological properties, making it a promising candidate for the development of new medications or the improvement of existing ones.
Used in Research and Development:
In the field of scientific research, 4-Hydroxy Duloxetine serves as a valuable compound for studying the metabolism, pharmacokinetics, and pharmacodynamics of Duloxetine. Understanding the properties and behavior of this metabolite can provide insights into the drug's mechanism of action, potential side effects, and ways to optimize its therapeutic use.
Used in Drug Metabolism Studies:
4-Hydroxy Duloxetine is used as a reference compound in drug metabolism studies, helping researchers understand how the body processes and eliminates medications. This knowledge can be crucial in the design of safer and more effective drugs, as well as in predicting potential drug-drug interactions.
Used in Quality Control and Standardization:
In the pharmaceutical industry, 4-Hydroxy Duloxetine can be used as a reference standard for quality control and standardization purposes. It can help ensure the consistency, purity, and potency of Duloxetine-containing products, contributing to their overall safety and efficacy.

InChI:InChI=1/C18H19NO2S/c1-19-11-10-17(18-7-4-12-22-18)21-16-9-8-15(20)13-5-2-3-6-14(13)16/h2-9,12,17,19-20H,10-11H2,1H3

Downstream Products

• 741693-83-4 4-Hydroxy-Duloxetine Glucuronide