66217-26-3

Basic information

• Product Name: 6-Ethoxynaphthalene-2-carbonitrile,
• Synonyms: 6-Ethoxynaphthalene-2-carbonitrile,
• CAS NO: 66217-26-3
• Molecular Formula: C13H11NO
• Molecular Weight: 197.23254
• Mol File: 66217-26-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 103-105 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 359.3±15.0 °C(Predicted)
• Appearance: /
• Density: 1.13±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 6-Ethoxynaphthalene-2-carbonitrile,(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Ethoxynaphthalene-2-carbonitrile,(66217-26-3)
• EPA Substance Registry System: 6-Ethoxynaphthalene-2-carbonitrile,(66217-26-3)

Safety Data

• Hazardous Substances Data: 66217-26-3(Hazardous Substances Data)

Usage

Derivative of

Naphthalene

Common uses

Synthesis of pharmaceuticals and agrochemicals

Physical properties

Color: Colorless to yellow
Odor: Strong aromatic
Solubility: Insoluble in water, soluble in most organic solvents

Hazards

Can cause irritation to skin, eyes, and respiratory system upon exposure
Should be handled with care

Upstream product

• 66217-19-4 2-ethoxy-6-bromo-naphthalene 
• 544-92-3 copper(I) cyanide 
• 15231-91-1 6-bromo-naphthalen-2-ol 
• 74-96-4 ethyl bromide 
• 52927-22-7 6-cyano-2-naphthol 

Relevant articles and documents

Discovery of a sensitive, selective, and tightly binding fluorogenic substrate of bovine plasma amine oxidase

(Chemical Equation Presented) We report a novel fluorogenic substrate of bovine plasma amine oxidase (BPAO), namely, (2-(6-(aminomethyl)naphthalen-2- yloxy)ethyl)trimethylammonium (ANETA), which displays extremely tight binding to BPAO (Km 183 ± 14 nM) and yet is metabolized fairly quickly (kcat 0.690 ± 0.010 s-1), with the aldehyde turnover product (2-(6-formylnaphthalen-2-yloxy)ethyl)trimefhylammonium serving as a real time reporting fluorophore of the enzyme activity. This allowed for the development of a fluorometric noncoupled assay that is 2 orders of magnitude more sensitive than the spectrophotometric benzylamine assay. The discovery of ANETA involved elaboration of the lead compound 6-methoxy-2-naphthalene- methaneamine by structure-based design, which recognized the ancillary cation binding site of BPAO as the most significant structural features controlling binding affinity. Structure-based design further ensured a high level of selectivity: ANETA is a good substrate of BPAO but is not a substrate of either porcine kidney diamine oxidase (pkDAO) or rat liver monoamine oxidase (MAO-B). ANETA represents the first highly sensitive, selective, and tight binding fluorogenic substrate of a copper amine oxidase that is able to respond directly to the enzyme activity in real time.

Synthetic inhibitors of serine proteinases

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