66232-40-4Relevant articles and documents
SUBSTITUTED FUSED PYRIMIDINONE COMPOUNDS
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Page/Page column 34; 35, (2017/12/15)
Provided herein are novel fused pyrimidinone derivatives of Formula (I) and synthetic intermediates that are useful in preparing the compounds of formula (I). Further provided herein is a method for preparation of a compound of formula (I) or intermediate
One-pot multicomponent synthesis of medicinally important purine quinazolinone derivatives
Sawant, Sanghapal D.,Srinivas, Mahesuni,Reddy, G.Lakshma,Rao, V.Venkateswar,Singh, Parvinder Pal,Vishwakarma, Ram A.
supporting information, p. 6195 - 6198 (2013/01/14)
Herein, a protocol that involves microwave-assisted, multicomponent one-pot synthetic strategy for the construction of the medicinally important purine quinazolinone scaffold is reported. A series of compounds are prepared by cyclization and condensation
Synthesis and antitumor activity of fused quinoline derivatives. V. Methylindolo[3,2-b]quinolines
Takeuchi, Yasuo,Kitaomo, Masayuki,Chang, Ming-Rong,Shirasaka, Shota,Shimamura, Chinami,Okuno, Yumiko,Yamato, Masatoshi,Harayama, Takashi
, p. 2096 - 2099 (2007/10/03)
Indolo[3,2-b]quinoline derivatives (1b-i) with a methyl group at each possible position have been synthesized. The 1-methyl (1b) and 9-methyl (1i) derivatives were inactive, but the 3-methyl (1d), 4-methyl (1e), and 6- methyl (1f) derivatives exhibited high treatment/control (T/C) value and cure rates against leukemia P388 in mice. These results indicated that modification of indolo[3,2-b]quinoline derivatives at 3, 4, and 6 positions may be useful approach for lead optimization.