66269-78-1

Basic information

• Product Name: 2-(4,5-Dihydro-3H-pyrrol-2-yl)-pyridine
• Synonyms: 2-(4,5-Dihydro-3H-pyrrol-2-yl)-pyridine;4-(3,4-dihydro-2H-pyrrol-5-yl)pyridine
• CAS NO: 66269-78-1
• Molecular Formula: C9H10N2
• Molecular Weight: 146.19
• Mol File: 66269-78-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 372.4°C at 760 mmHg
• Flash Point: 179°C
• Appearance: /
• Density: 1.17g/cm³
• Vapor Pressure: 2.06E-05mmHg at 25°C
• Refractive Index: 1.578
• CAS DataBase Reference: 2-(4,5-Dihydro-3H-pyrrol-2-yl)-pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4,5-Dihydro-3H-pyrrol-2-yl)-pyridine(66269-78-1)
• EPA Substance Registry System: 2-(4,5-Dihydro-3H-pyrrol-2-yl)-pyridine(66269-78-1)

Safety Data

• Hazardous Substances Data: 66269-78-1(Hazardous Substances Data)

Usage

General Description

2-(4,5-Dihydro-3H-pyrrol-2-yl)-pyridine, also known as DHPD, is an organic compound with a molecular formula C10H11N. It is a pyrrole derivative with a pyridine ring, and it is commonly used as a ligand in coordination chemistry. DHPD has been studied for its potential applications in catalysis and material science, particularly in the development of new functional materials. It is also used in the synthesis of pharmaceuticals and agrochemicals. DHPD has a unique molecular structure that gives it interesting properties, making it an important compound in various fields of research and industry.

InChI:InChI=1/C17H22ClNO/c1-16(2)13-7-8-17(16,3)15(10-13)19-20-11-12-5-4-6-14(18)9-12/h4-6,9,13H,7-8,10-11H2,1-3H3/b19-15-

Upstream product

• 88-12-0 1-ethenyl-2-pyrrolidinone 
• 1570-45-2 isonicotinic acid ethylester 
• 90915-42-7 3-isonicotinoyl-pyrrolidin-2-one 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 

Downstream Products

• 66269-75-8 4-(pyrrolidin-2-yl)pyridine 

Relevant articles and documents

Pyrrolidine amides of pyrazolodihydropyrimidines as potent and selective KV1.5 blockers

Design and synthesis of pyrazolodihydropyrimidines as KV1.5 blockers led to the discovery of 7d as a potent and selective antagonist. This compound showed atrial selective prolongation of effective refractory period in rabbits and was selected for clinical development.

Diastereoselective synthesis of cyclic 1,3-aminoalcohols bearing CF3(CCl3)-groups

An aldol-type reaction of cyclic imines and cyclic lactims with carbonyl compounds activated by electron withdrawing trifluoromethyl or trichloromethyl groups proceeded without any catalyst under mild condition. β-Hydroxymethyl substituted cyclic imines or imidates are formed as a result of the reaction. The reduction of the prepared imines leads stereoselectively to the cyclic 1,3-aminoalcohols. Application of methyl trifluoropyruvate in this transformation opens an opportunity for the synthesis of γ-aminoacids derivatives which contain pyrrolidine moiety.