6628-69-9

Basic information

• Product Name: 4-(biphenyl-4-yloxy)aniline
• Synonyms: 4-(1,1'-biphenyl-4-yloxy)aniline; benzenamine, 4-([1,1'-biphenyl]-4-yloxy)-
• CAS NO: 6628-69-9
• Molecular Formula: C₁₈H₁₅NO
• Molecular Weight: 261.3178
• Mol File: 6628-69-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 432.4°C at 760 mmHg
• Flash Point: 223°C
• Density: 1.148g/cm³
• Vapor Pressure: 1.11E-07mmHg at 25°C
• Refractive Index: 1.635
• CAS DataBase Reference: 4-(biphenyl-4-yloxy)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(biphenyl-4-yloxy)aniline(6628-69-9)
• EPA Substance Registry System: 4-(biphenyl-4-yloxy)aniline(6628-69-9)

Safety Data

• Hazardous Substances Data: 6628-69-9(Hazardous Substances Data)

Usage

General Description

4-(biphenyl-4-yloxy)aniline, also known as biphenyl-4-yloxyphenylamine, is a chemical compound consisting of a biphenyl group attached to an aniline group. It is often used as a building block in the synthesis of organic compounds and is also a common intermediate in the production of dyes and pigments. This chemical can be toxic and should be handled with care, as it has the potential to cause skin and eye irritation. Additionally, it may be harmful if swallowed or inhaled. It is important to follow proper safety precautions when working with 4-(biphenyl-4-yloxy)aniline to prevent exposure and potential health risks.

Upstream product

• 6641-61-8 4-(4-nitrophenoxy)-1,1'-biphenyl 
• 100-00-5 4-chlorobenzonitrile 
• 92-69-3 4-Phenylphenol 

Downstream Products

• 1244974-78-4 C₄₇H₃₁F₆N₃O₈ 
• 1366234-36-7 C₂₂H₁₈N₄O 

Relevant articles and documents

Synthesis of a novel polyimide used as liquid crystal vertical alignment layers

A novel functional diamine containing a triphenylamine moiety and a biphenyl group, N,N-bis(4-aminophenyl)-4-(biphenyl)-4′-aminophenyl ether (N0), was successfully synthesized and characterized. A series of polyimides (PIs) and poly(amic acid)s (PAAs) were synthesized from cyclobutane-1,2,3,4-tetracarboxylic dianhydride (CBDA), 2,2′-bis(trifluoromethyl)-[1,1′-biphenyl]-4,4′-diamine (TFDB), 4-dodecyloxy-phenyl-4′,4″-diaminotriphenylamine (C12) and the newly synthesised diamine monomer (N0) through a conventional two-step procedure that included a ring-opening polyaddition to give polyamic acids, followed by thermal cyclodehydration. Pretilt angles of a liquid crystal (LC) cell fabricated with the PIs were measured, and the rubbing resistance of PIs containing different sidechain structures was investigated. PI1 with a rigid biphenyl side chain could induce LC parallel alignment after the rubbing process. Although PI3 containing a flexible alkyl side chain could induce LC vertical alignment before the rubbing process, it only induced LC parallel alignment after the rubbing process. However, PI2 containing both rigid biphenyl side chains and flexible alkyl side chains could induce LC vertical alignment before and after the rubbing process. A new method for improving the rubbing resistance of PIs and a generation mechanism of rubbing resistance have been proposed. In addition, all PI films showed high thermal stability and high transmittance in the wavelength range of 400-700 nm.

A focused library of protein tyrosine phosphatase inhibitors

Protein tyrosine phosphatases such as PTP1B and YopH are potential targets for the development of therapeutic agents against a variety of pathological conditions including diabetes, obesity, and infection by the bacterium Yersinia pestis. A focused library of bidentate α-ketoacid-based inhibitors has been screened against several tyrosine phosphatases. Compound 2a has IC 50 values of 43 and 220 nM against YopH and PTP1B, respectively, and shows a 30-fold selectivity for PTP1B over the closely related phosphatase TCPTP.