66280-25-9 Usage
Description
Gomisin J is a naturally occurring compound derived from the Schisandra fruit, known for its potential therapeutic properties and bioactivities. It is characterized by its unique chemical structure and has been the subject of research for its potential health benefits.
Uses
Used in Pharmaceutical Industry:
Gomisin J is used as an anti-ovarian cancer agent for its potential to inhibit the growth and progression of ovarian cancer cells. Its bioactive properties make it a promising candidate for the development of novel therapeutics in oncology.
Additionally, gomisin J is used as an inhibitor of glucuronidation for SN-8, a metabolite of the drug doxorubicin. This application is significant in the pharmaceutical industry as it can help modulate the activity and metabolism of certain drugs, potentially improving their efficacy and safety profile.
Check Digit Verification of cas no
The CAS Registry Mumber 66280-25-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,2,8 and 0 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 66280-25:
(7*6)+(6*6)+(5*2)+(4*8)+(3*0)+(2*2)+(1*5)=129
129 % 10 = 9
So 66280-25-9 is a valid CAS Registry Number.
InChI:InChI=1/C22H28O6/c1-11-7-13-9-15(23)19(25-3)21(27-5)17(13)18-14(8-12(11)2)10-16(24)20(26-4)22(18)28-6/h9-12,23-24H,7-8H2,1-6H3/t11-,12+
66280-25-9Relevant articles and documents
Total Syntheses of the Lignans Isolated from Schisandra Chinensis
Tanaka, Masahide,Ohshima, Toshihiro,Mitsuhashi, Hiroshi,Maruno, Masao,Wakamatsu, Takeshi
, p. 11693 - 11702 (1995)
The total syntheses of wuweizisu C (4), gomisin J (6), gomisin N (7), and γ-schizandrin (8) having natural configuration were accomplished in a stereoselective manner.The catalytic hydrogenation or the metal mediated 1,4-reduction of the tetracyclic lactones (12, 17, 22, 30) played the significant role for the stereoselective introduction of C6, C7 dimethyl moiety.Furthermore, the neighboring carbonyl group assisted regioselective demethylation of 5 was essential for the synthesis of 6.