66308-22-3

Basic information

• Product Name: Carbamic acid, (4,5-dihydro-1-methyl-5-phenyl-1H-imidazol-2-yl)-, 2-methylpropyl ester
• CAS NO: 66308-22-3
• Molecular Formula: C15H21N3O2
• Molecular Weight: 275.351
• Mol File: 66308-22-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Carbamic acid, (4,5-dihydro-1-methyl-5-phenyl-1H-imidazol-2-yl)-, 2-methylpropyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, (4,5-dihydro-1-methyl-5-phenyl-1H-imidazol-2-yl)-, 2-methylpropyl ester(66308-22-3)
• EPA Substance Registry System: Carbamic acid, (4,5-dihydro-1-methyl-5-phenyl-1H-imidazol-2-yl)-, 2-methylpropyl ester(66308-22-3)

Safety Data

• Hazardous Substances Data: 66308-22-3(Hazardous Substances Data)

Upstream product

• 89146-05-4 N¹-methyl-1-phenyl-ethanediyldiamine; dihydrochloride 
• 539-92-4 diisobutyl carbonate 

Relevant articles and documents

Synthesis and central nervous system properties of 2-[(alkoxycarbonyl)amino]-4(5)-phenyl-2-imidazolines

A series of 2-[(alkoxycarbonyl)amino]-4(5)-phenyl-2-imidazolines was prepared and evaluated for central nervous system (CNS) effects (antidepressant, anticonvulsant, muscle relaxant, and depressant) in animal models. Some separation of those CNS activities was achieved through substitutions on the phenyl and imidazoline moieties. Halo-substituted phenyl compounds were among the most potent antidepressants in this series, while imidazole N-alkylation produced compounds with increased depressant effects (loss of righting reflex, mouse behavior). Comparison of in vitro and in vivo data for pairs of 2-[(methoxycarbonyl)amino]-4(5)-phenyl-2-imidazolines and their parent, 2-amino-4(5)-phenyl-2-imidazolines, suggests that the title compounds were prodrugs for the 2-amino-4(5)-phenyl-2-imidazolines in inhibition of norepinephrine reuptake.