6635-31-0Relevant articles and documents
INDAZOLYL THIADIAZOLAMINES AND RELATED COMPOUNDS FOR INHIBITION OF RHO-ASSOCIATED PROTEIN KINASE AND THE TREATMENT OF DISEASE
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Paragraph 00372, (2016/09/22)
The invention provides indazolyl thiadiazolamines and related compounds, pharmaceutical compositions, methods of inhibiting Rho-associated protein kinase, and methods of treating inflammatory disorders, immune disorders, fibrotic disorders, and other medical disorders using such compounds. An exemplary indazolyl thiadiazolamine compound is an N-(5-[5-[(1H4ndazol-5-yl)amino]-1,3,4-thiadiazol-2-yl]pyridin-3-yl)acetamide compound.
A 6-hydroxy-5-nitro-nicotinic acid synthetic method and its separating and purifying method
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Paragraph 0045-0064, (2018/02/04)
The invention discloses a synthetic method and a separation purification method of 6-hydroxyl-5-nitro niacin and belongs to the field of fine chemical engineering. According to the method, 6-hydroxyl niacin is used as a raw material and is subjected to pre-nitration reaction under the action of concentrated sulfuric acid, concentrated nitric acid and a catalyst ammonium bisulfate, nitration reaction, crystal separation purification and the like to obtain highly purified 6- hydroxyl-5-nitro niacin to meet purity requirements on midbody by pharmaceutical synthetic fields. The synthetic method has the advantages of being simple in synthetic process, mild in condition, high in yield, high in purity of obtained product, easy to operate and the like and is suitable for industrial production.
Development of a solid-supported biotinylation reagent for efficient biotin labeling of SH groups on small molecules
Fukumoto, Kentarou,Adachi, Kumi,Kajiyama, Akihiro,Yamazaki, Yuri,Yakushiji, Fumika,Hayashi, Yoshio
supporting information; experimental part, p. 535 - 538 (2012/03/11)
We report here the design and synthesis of a novel and selective SH-group biotinylating reagent, KSH-1 (1), for the biotinylation of small molecules using solid phase chemistry. The results demonstrate that 1 efficiently biotinylated a small molecule, cap