66367-05-3 Usage
General Description
7-Chloro-3,4-dihydro-1H-Quinoxalin-2-one, also known as Clomethiazole, is a synthetic chemical compound with sedative and hypnotic properties. It acts as a central nervous system depressant, used in the treatment of alcohol withdrawal and to reduce anxiety and tension. It works by enhancing the inhibitory effects of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain, leading to a calming and relaxing effect on the body. Clomethiazole has a potential for abuse and addiction, and it may cause drowsiness, dizziness, and impaired coordination as side effects. It is important to use this chemical under the guidance of a healthcare professional to avoid misuse and potential adverse effects.
Check Digit Verification of cas no
The CAS Registry Mumber 66367-05-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,3,6 and 7 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 66367-05:
(7*6)+(6*6)+(5*3)+(4*6)+(3*7)+(2*0)+(1*5)=143
143 % 10 = 3
So 66367-05-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H7ClN2O/c9-5-1-2-6-7(3-5)11-8(12)4-10-6/h1-3,10H,4H2,(H,11,12)
66367-05-3Relevant articles and documents
New synthesis of diazepino[3,2,1-ij]quinoline and pyrido[1,2,3-de] quinoxalines via addition-elimination followed by cycloacylation
Baraldi, Pier Giovanni,Ruggiero, Emanuela,Tabrizi, Mojgan Aghazadeh
, p. 101 - 105 (2014/02/14)
This paper describes a convenient and efficient synthesis of new fused tricyclic diazepino[3,2,1-ij]quinolines and substituted pyrido[1,2,3-de] quinoxalines. o-Phenylenediamines are transformed in the tricycle nucleus in only a few-step synthetic sequence
Reaction of 4-substituted 1,2-phenylenediamine with chloroacetic acid and α, β-unsaturated carboxylic acids: Determination of the structure of the isomers formed using long-range carbon-proton coupling
Kalyanam, Nagabhushanam,Manjunatha, Sulur G
, p. 415 - 420 (2007/10/02)
The reaction between 4-chloro-1,2-phenylenediamine with sodium salt of chloroacetic acid yields 8-chlorotetrahydroquinoxalin-2-one, o-Phenylenediamines substituted at position-4 yield a single benzodiazepinone on reaction with α,β-unsaturated aliphatic carboxylic acids.The structures of the products formed are established from 13C NMR of the products and their acyl derivatives, sometimes, using long range carbon-proton couplings.
