6638-35-3

Basic information

• Product Name: 2-phenyl-5,6-dihydro-4H-1,3-thiazine
• CAS NO: 6638-35-3
• Molecular Formula: C₁₀H₁₁NS
• Molecular Weight: 177.266
• Mol File: 6638-35-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 270.3°C at 760 mmHg
• Flash Point: 117.3°C
• Density: 1.13g/cm³
• Vapor Pressure: 0.0114mmHg at 25°C
• Refractive Index: 1.616
• CAS DataBase Reference: 2-phenyl-5,6-dihydro-4H-1,3-thiazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-5,6-dihydro-4H-1,3-thiazine(6638-35-3)
• EPA Substance Registry System: 2-phenyl-5,6-dihydro-4H-1,3-thiazine(6638-35-3)

Safety Data

• Hazardous Substances Data: 6638-35-3(Hazardous Substances Data)

Upstream product

• 36926-17-7 N-(3-hydroxypropyl)benzothioamide 
• 109-70-6 1.3-chlorobromopropane 
• 2227-79-4 benzenecarbothioamide 
• 10554-88-8 1-thiobenzoyl-azetidine 
• 18370-81-5 (3-bromopropyl)amine 
• 13609-09-1 N-(3-hydroxypropyl)benzamide 
• 10554-29-7 N-(3-chloropropyl)benzamide 
• 98-88-4 benzoyl chloride 
• 3420-41-5 2-Phenyl-5,6-dihydro-4H-[1,3]oxazine 
• 100-52-7 benzaldehyde 
• 5003-71-4 3-bromopropylamine hydrochloride 
• 932-90-1 Benzaldoxime 
• 129348-90-9 3-benzoylaminopropyl acetate 

Downstream Products

• 70310-01-9 7-tert-butyl-8-oxo-6-phenyl-(6rH)-5-thia-1-aza-bicyclo[4.2.0]octane-7t-carbonitrile 
• 58134-47-7 (8-oxo-6-phenyl-5-thia-1-aza-bicyclo[4.2.0]oct-7-yl)-carbamic acid tert-butyl ester 
• 57050-14-3 7,7-dichloro-6-phenyl-5-thia-1-aza-bicyclo[4.2.0]octan-8-one 
• 57050-15-4 9,9-dichloro-6-dichloromethylene-9a-phenyl-tetrahydro-[1,3]thiazino[3,2-c][1,3]oxazin-8-one 
• 57050-13-2 6,7,7-triphenyl-5-thia-1-aza-bicyclo[4.2.0]octan-8-one 
• 36804-24-7 7-indol-3-yl-6-phenyl-5-thia-1-aza-bicyclo[4.2.0]octan-8-one 
• 37958-33-1 7c-methoxy-6-phenyl-(6rH)-5-thia-1-aza-bicyclo[4.2.0]octan-8-one 
• 50708-32-2 (8-oxo-6-phenyl-5-thia-1-aza-bicyclo[4.2.0]oct-7-yl)-carbamic acid benzyl ester 
• 57050-16-5 7-chloro-6-phenyl-5-thia-1-aza-bicyclo[4.2.0]octan-8-one 
• 37958-32-0 (+/-)-trans-7-phenoxy-6-phenyl-5-thia-1-azabicyclo[4.2.0]octan-8-one 
• 64468-47-9 7-phenoxy-6-phenyl-5-thia-1-aza-bicyclo[4.2.0]octan-8-one 
• 114968-01-3 6,7-diphenylcepham 
• 79593-67-2 2-Phenyl-N-methyl-5,6-dihydro-1,3-thiazinium tetrafluoroborate 
• 88252-55-5 7-(4-Chloro-phenoxy)-6-phenyl-5-thia-1-aza-bicyclo[4.2.0]octan-8-one 

Relevant articles and documents

Microwave-Assisted Synthesis of 2-Substituted 2-Thiazolines and 5,6-Dihydro-4 H -1,3-thiazines

An efficient and general method for the synthesis of 2-substituted thiazolines and 5,6-dihydro-4 H -1,3-thiazines is developed via microwave-assisted ring closure of ω-thioamidoalcohols promoted by ethyl polyphosphate (PPE). The cyclization reaction involves an S N 2-type mechanism and features the advantages of very short reaction times, high yields and a predictable stereochemical outcome. The acyclic precursors are prepared in high overall yields by an improved diacylation-thionation-saponification sequence from commercially available ω-amino alcohols. The whole process is metal-free and operationally simple.

Easy access to thiazolines and thiazines via tandem S-alkylation- cyclodeamination of thioamides/haloamines

This is the first report of a facile synthesis of thiazolines and thiazines from a self-catalyzed, water assisted tandem S-alkylation-cyclodeamination reaction of thioamides/haloamines. The reaction is clean and efficient with simple product work-up, and is applicable to a variety of substrates.

Synthesis of oxazines and thiazines by cyclodehydration of hydroxy amides and thioamides

Dihydro-1,3-oxazines and -thiazines were obtained by cyclodehydration of hydroxy amides and thioamides with PEG-linked Burgess reagent or under Mitsunobu conditions. Yields were generally higher with polymer-Burgess reagent, but both conditions failed to