6639-43-6

Basic information

• Product Name: triphenylacetonitrile
• Synonyms: benzeneacetonitrile, alpha,alpha-diphenyl-
• CAS NO: 6639-43-6
• Molecular Formula: C₂₀H₁₅N
• Molecular Weight: 269.34
• Mol File: 6639-43-6.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 392.1°C at 760 mmHg
• Flash Point: 197.8°C
• Density: 1.109g/cm³
• Vapor Pressure: 2.35E-06mmHg at 25°C
• Refractive Index: 1.609
• CAS DataBase Reference: triphenylacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: triphenylacetonitrile(6639-43-6)
• EPA Substance Registry System: triphenylacetonitrile(6639-43-6)

Safety Data

• Hazardous Substances Data: 6639-43-6(Hazardous Substances Data)

Usage

General Description

Triphenylacetonitrile is a chemical compound with the formula C20H15N. It is a nitrile derivative of triphenylmethane, and is commonly used as a building block in organic synthesis. Triphenylacetonitrile is a colorless to light yellow solid that is insoluble in water but soluble in organic solvents. It possesses a strong, sweet, floral odor and is used in the production of pharmaceuticals, dyes, and other organic chemicals. It is also used as a precursor in the synthesis of various organic compounds, including pharmaceutical intermediates and pesticides. Triphenylacetonitrile is handled and used with proper precautions due to its potential health hazards, including skin and eye irritation.

Upstream product

• 613-90-1 benzoyl cyanide 
• 60-29-7 diethyl ether 
• 18773-77-8 methyl(phenyl)cyanamide 
• 4303-71-3 triphenylmethyl sodium 
• 596-43-0 bromo-triphenyl-methane 
• 4439-05-8 tris(4',4'',4'''-aminophenyl) acetonitrile 
• 151-50-8 potassium cyanide 
• 52460-85-2 α-bromo-α-phenylbenzeneacetonitrile 
• 41401-04-1 triphenyl-acetaldehyde-oxime 
• 108-24-7 acetic anhydride 
• 140-29-4 phenylacetonitrile 
• 71-43-2 benzene 
• 100313-60-8 2-methyl-[1,3]dioxolane-2-carbonitrile 
• 341-02-6 trityl tetrafluoroborate 

Downstream Products

• 26536-35-6 triphenylacetamide 
• 519-73-3 triphenylmethane 
• 595-91-5 triphenylacetic acid 
• 109864-56-4 2,2,2-triphenylethylamine 
• 861296-52-8 tris-(4-nitro-phenyl)-acetonitrile 
• 92-52-4 biphenyl 
• 13031-13-5 2-methoxy-2-phenylacetonitrile 
• 42365-04-8 triphenylacetaldehyde 
• 74-90-8 hydrogen cyanide 
• 5424-86-2 2,3-diphenylsuccinonitrile 
• 140-29-4 phenylacetonitrile 
• 140945-16-0 1-[4,6-bis(allylamino)-2-s-triazinyl]-4-(2,2,2-triphenylethylamino)piperidine 
• 873990-13-7 (2,2,2-triphenyl-ethyl)-carbamic acid ethyl ester 
• 4439-05-8 tris(4',4'',4'''-aminophenyl) acetonitrile 

Relevant articles and documents

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I2/Li2CO3-promoted cyanation of diarylalcohols through a dual activation process

One-step base promoted strategy for cyanation of α,α-diaryl alcohols has been developed under mild and transition metal-free conditions. This method provides a straightforward and facile way towards the synthesis of β,γ-unsaturated nitriles and α-phenylnitiriles from α-vinyl carbinols and α,α-diaryl methanols, respectively, up to 99% yield. Moreover, various azides and ethers could also be accessed from their respective nucleophiles under standard reaction conditions.

Lewis Acid Catalyzed Synthesis of Cyanidophosphates

Salts containing new cyanido(fluorido)phosphate anions of the general formula [PF6-n(CN)n]- (n=1-4) were synthesized by a very mild Lewis-acid-catalyzed synthetic protocol and fully characterized. All [PF6-n(CN)n]- (n=1-4) salts could be isolated on a preparative scale. It was also possible to detect the [PF(CN)5]- but not the [P(CN)6]- anion. The best results with respect to purity, yield, and low cost were obtained when the F-/CN- substitution reactions were carried out in ionic liquids. Cyanido(fluorido)phosphates: Salts containing [PF6-n(CN)n]- (n=1-4) ions were isolated on a preparative scale by utilizing Lewis acids (LA) catalysts under mild conditions (see equation). The best results with respect to purity, yield, and low cost were obtained when the F-/CN- substitution reactions were carried out in ionic liquids.

Efficient assembly of α-aryl and α-vinyl nitriles via iron-catalyzed ether bond activation

A novel and practical method for the synthesis of diverse α-aryl and α-vinyl nitriles was developed via an iron-catalyzed sp3 C-O ether bond cleavage with C-C bond formation in the reaction of π-activated ethers with TMSCN.