66491-04-1

Basic information

• Product Name: 7-Iodo-3,4-dihydroisoquinolin-1(2H)-one
• Synonyms: 7-Iodo-3,4-dihydroisoquinolin-1(2H)-one
• CAS NO: 66491-04-1
• Molecular Formula: C₉H₈INO
• Molecular Weight: 273.07039
• Mol File: 66491-04-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-Iodo-3,4-dihydroisoquinolin-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Iodo-3,4-dihydroisoquinolin-1(2H)-one(66491-04-1)
• EPA Substance Registry System: 7-Iodo-3,4-dihydroisoquinolin-1(2H)-one(66491-04-1)

Safety Data

• Hazardous Substances Data: 66491-04-1(Hazardous Substances Data)

Usage

General Description

7-Iodo-3,4-dihydroisoquinolin-1(2H)-one is a chemical compound with the molecular formula C9H8INO. It is a halogenated isoquinolinone derivative, which is a class of compounds known for their diverse biological activities. 7-Iodo-3,4-dihydroisoquinolin-1(2H)-one has been studied for its potential to act as a pharmaceutical intermediate and has shown promise for use in the synthesis of various pharmaceutical compounds. Its structure consists of an isoquinolinone core with a 7-iodo substituent, which gives it unique chemical and physical properties. Further research is needed to fully understand the potential applications and properties of 7-Iodo-3,4-dihydroisoquinolin-1(2H)-one.

Upstream product

• 66491-03-0 7-amino-3,4-dihydroisoquinoline-1(2H)-one 
• 6552-60-9 3,4-dihydro-2H-isoquinoline-1-thione 
• 22245-96-1 7-nitro-3,4-dihydro-2H-isoquinolin-1-one 
• 2257-09-2 Phenethyl isothiocyanate 
• 1196-38-9 3,4-dihydroisoquinolin-1(2H)-one 
• 86288-79-1 2,7-Dinitro-3,4-dihydroisocarbostyryl 
• 6970-83-8 ethyl-N-(2-phenethyl)carbamate 
• 64-04-0 phenethylamine 
• 7681-65-4 copper(l) iodide 
• 73918-57-7 p-Iodophenylethylamine 

Downstream Products

• 62541-62-2 2-(2-Aminoethyl)-5-iodobenzoic acid hydrochloride 
• 1027936-01-1 [1-Oxo-7-(1-trityl-1H-imidazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-acetic acid 
• 183622-32-4 ethyl 7-(1-trityl-4-imidazolyl)-3,4-dihydro-1(1H)-isoquinolinone-2-acetate 
• 1027838-11-4 (S)-3-{2-[1-Oxo-7-(1-trityl-1H-imidazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-acetylamino}-3-pyridin-3-yl-propionic acid ethyl ester 
• 62541-63-3 5-Iodo-2-(2-pyrrol-1-ylethyl)benzoic acid 

Relevant articles and documents

Facile synthesis of 5-To 7-membered benzolactam compounds via strongly facilitated electrophilic aromtic substitution reaction

We employed our system to activate aromatic ring-Tethered carbamate compounds with trifluoromethanesulfonic acid to obtain benzolactams with 5-To 7-membered rings, and examined the substrate scope and limitations of this activation method. In 5-membered ring formation, a halogen group on the aromatic ring did not greatly affect the reaction yield, but other electron-donating groups inhibited the cyclization reaction, and various side-reactions occurred. In 7-membered ring formation, eletron-donating groups on aromatic ring promoted the cyclization reaction, but cyclization of electron-deficient aromatic rings did not proceed well. The 6-membered ring formation reaction showed the greatest substrate generality.

17a-HYDROXYLASE/C17,20-LYASE INHIBITORS

The present invention provides compounds of Formula (I), or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, A and n are as defined herein. A deuteriated derivative of the compound of Formula (I) is also provided.

Non-peptide glycoprotein IIb/IIIa antagonists. 11. Design and in vivo evaluation of 3,4-dihydro-1(1H)-isoquinolinone-based antagonists and ethyl ester prodrugs

The structure-activity relationship of a series of orally active glycoprotein IIb/IIIa antagonists containing a nitrogen heterocycle grafted onto a 3,4-dihydro-1(1H)-isoquinolinone core is described. These compounds are structurally novel analogs of the p