66496-82-0

Basic information

• Product Name: 3-CHLOROMETHYL-1-METHYLPIPERIDINE HYDROCHLORIDE
• Synonyms: 3-CHLOROMETHYL-1-METHYLPIPERIDINE HYDROCHLORIDE;3-chloromethyl-1-methylpiperidinium chloride;3-Chloromethyl-1-methylpiperidineHCl;Einecs 266-381-2;3-Chloromethyl-1-methylpiperidine hydrochloride 98%
• CAS NO: 66496-82-0
• Molecular Formula: C₇H₁₄ClN*ClH
• Molecular Weight: 184.11
• EINECS: 266-381-2
• Product Categories: API intermediates;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Piperidines;PiperidinesHeterocyclic Building Blocks
• Mol File: 66496-82-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 170-172 °C(lit.)
• Boiling Point: 183.8°C at 760 mmHg
• Flash Point: 65°C
• Appearance: /
• Vapor Pressure: 0.757mmHg at 25°C
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: 3-CHLOROMETHYL-1-METHYLPIPERIDINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLOROMETHYL-1-METHYLPIPERIDINE HYDROCHLORIDE(66496-82-0)
• EPA Substance Registry System: 3-CHLOROMETHYL-1-METHYLPIPERIDINE HYDROCHLORIDE(66496-82-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 66496-82-0(Hazardous Substances Data)

Usage

General Description

3-CHLOROMETHYL-1-METHYLPIPERIDINE HYDROCHLORIDE is a chemical compound with potential applications in pharmaceuticals and organic synthesis. It is a white to off-white crystalline powder that is soluble in water and ethanol. The compound is a derivative of piperidine, a heterocyclic organic compound, and its chloromethyl and methyl substituents make it useful for the synthesis of various pharmaceutical drugs and other organic compounds. As a hydrochloride salt, it is commonly used as a precursor in the production of drugs and may have potential use as a pharmaceutical ingredient. Additionally, it may also have applications in research and development in the field of organic chemistry.

InChI:InChI=1/C7H14ClN.ClH/c1-9-4-2-3-7(5-8)6-9;/h7H,2-6H2,1H3;1H

Upstream product

• 7583-53-1 1-methyl-3-hydroxymethylpiperidine 

Downstream Products

• 3689-38-1 2-chloro-10-[(1-methylpiperidin-3-yl)methyl]-10H-phenothiazine 
• 174347-05-8 1-Methyl-3-(4-nitro-phenoxymethyl)-piperidine 
• 1348503-37-6 N-(1-methylethyl)-2-[3-[3-(methyloxy)phenyl]-7-{[(1-methyl-3-piperidinyl)methyl]oxy}-1-oxopyrrolo[1,2-a]pyrazin-2(1H)-yl]acetamide 
• 1100094-58-3 3-(1H-benzimidazol-2-yl)-5-[3-methoxy-4-[(1-methylpiperidin-3-yl)methoxy]phenyl]pyrazin-2-amine 
• 417714-20-6 N-(4-(6-Cyano-7-((1-methylpiperidin-3-yl)methoxy)-4-quinolyl)oxy-2-fluorophenyl)-N'-(4-fluorophenyl)urea 
• 417723-95-6 4-(4-amino-3-fluorophenoxy)-7-(1-methylpiperidin-3-ylmethoxy) quinoline-6-carbonitrile 
• 147847-97-0 2-(2,4-dichlorophenyl)-3-(1-methylpiperidin-3-yl)propionitrile 
• 942133-90-6 1-[2-hydroxy-3-methyl-4-[(1-methyl-3-piperidinyl)methoxy]phenyl]ethanone 

Relevant articles and documents

3-(methyleneaminoxy)methylpiperidine derivatives as uptake inhibitors of biogenic amines in the brain synaptosomal fraction

A series of 3-(methyleneaminoxy)methylpiperidines (5a-h) and their corresponding N-methyl derivatives (6a-h) with a variety of substituents on the imino carbon were synthesized and tested for their potential antidepressant properties; their capacity to inhibit the re-uptake of biogenic amines (NA, 5-HT and DA) in rabbit brain synaptosomal fractions was also evaluated.The biological results obtained for the piperidine derivatives 5a-h and 6a-h and viloxazine 1, the reference drug, on the 3 re-uptake systems revealed that compounds 5 and 6 are generally able to inhibitbiogenic amine uptake.The IC50 values for 5 and 6 were often lower than that of viloxazine 1, in particular for the serotonin- and/or dopamine-uptake systems.A higher activity was found for compounds substituted with at least one phenyl ring on the imino carbon with respect to completely aliphatic systems, and for N-unsubstituted compounds with respect to N-methyl-substituted compounds. 3-(methyleneaminoxy)methylpiperidine derivative / NA uptake inhibitor / 5-HT uptake inhibitor / DA uptake inhibitor / antidepressant drug