66542-37-8 Usage
Description
(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl butanoate is a chemical compound with the molecular formula C9H11FN2O4. It is a derivative of the pyrimidine compound and is commonly used in the synthesis of pharmaceuticals. (5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl butanoate has a unique chemical structure that makes it a versatile building block for the synthesis of new compounds with potential therapeutic properties.
Uses
Used in Pharmaceutical Industry:
(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl butanoate is used as an intermediate in the synthesis of pharmaceuticals for its potential applications in the development of antiviral and antitumor drugs. It has the ability to inhibit the growth of certain types of cancer cells and viruses, making it a promising candidate for the treatment of various diseases.
Used in Antiviral Applications:
In the field of antiviral research, (5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl butanoate is used as an active pharmaceutical ingredient for its potential to inhibit the growth of viruses. Its unique chemical structure allows it to target specific viral mechanisms, providing a potential therapeutic option for viral infections.
Used in Antitumor Applications:
(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl butanoate is used as an anticancer agent in the development of drugs targeting the growth of certain types of cancer cells. Its ability to inhibit cancer cell growth makes it a valuable component in the creation of novel cancer treatments.
Used in Neurological Disorder Treatment:
(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl butanoate has been studied for its potential use in the treatment of neurological disorders. Its unique properties may contribute to the development of new therapies for conditions affecting the nervous system.
Used as an Antibacterial Agent:
In the field of antibacterial research, (5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl butanoate is used as a potential active ingredient for the development of new antibiotics. Its ability to target and inhibit bacterial growth may lead to the creation of novel treatments for bacterial infections.
Check Digit Verification of cas no
The CAS Registry Mumber 66542-37-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,5,4 and 2 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 66542-37:
(7*6)+(6*6)+(5*5)+(4*4)+(3*2)+(2*3)+(1*7)=138
138 % 10 = 8
So 66542-37-8 is a valid CAS Registry Number.
66542-37-8Relevant articles and documents
1-Alkylcarbonyloxymethyl prodrugs of 5-fluorouracil (5-FU): Synthesis, physicochemical properties, and topical delivery of 5-FU
Taylor, H. Elizabeth,Sloan, Kenneth B.
, p. 15 - 20 (1998)
1-Alkylcarbonyloxymethyl (1-ACOM) prodrugs of 5-fluorouracil (5-FU) have been synthesized and characterized by their solubilities in isopropyl myristate (S(IPM)) and pH 4.0 buffer (S(H2O)), by their partition coefficients between isopropyl myristate (IPM) and pH 4.0 buffer (K) and by their abilities to deliver total 5-FU species into (C(s)) and through (J(l)) hairless mouse skin from an IPM vehicle. All of the prodrugs were much more lipophilic (S(IPM)) than 5-FU (>60 times), and two memberS of the series (alkyl = C1 and C2, acelyl- and propionyloxymethyl) were also more soluble in water than 5-FU. The two more water-soluble members gave larger J(l) values than the other members of the series, with C2 exhibiting the best biphasic solubility and the largest J(l) value (16 times that of 5-FU). The ability of the 1-ACOM-5-FU prodrugs to deliver total 5-FU species into skin (C(s)) was greater than the delivery of 5-FU by 5-FU, except for the last two members of series (alkyl = C7 and C9, octanoyl- and decanoyl-oxymethyl). However, the ratios of normalized C(s) to J(l) for the series was less than that exhibited by 5-FU, except for C7 and C9. Also, except for C9, significant amounts of intact prodrug as percentages of total 5-FU species were found in the receptor phases during the course of the diffusion cell experiments, ranging from 55% for C1 to 12% for C7.
5-Fluorouracil derivatives. IV. Synthesis of antitumor-active acyloxyalkyl-5-fluorouracils
Ozaki,Watanabe,Hoshiko,Mizuno,Ishikawa,Mori
, p. 733 - 738 (2007/10/02)
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