6655-25-0

Basic information

• Product Name: N-phenylpropane-1-sulfonamide
• Synonyms: 1-propanesulfonamide, N-phenyl-; 1-Propanesulfonanilide; N-Phenylpropane-1-sulfonamide
• CAS NO: 6655-25-0
• Molecular Formula: C₉H₁₃NO₂S
• Molecular Weight: 199.27
• Mol File: 6655-25-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 312.3°C at 760 mmHg
• Flash Point: 142.6°C
• Density: 1.222g/cm³
• Vapor Pressure: 0.000535mmHg at 25°C
• Refractive Index: 1.565
• CAS DataBase Reference: N-phenylpropane-1-sulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-phenylpropane-1-sulfonamide(6655-25-0)
• EPA Substance Registry System: N-phenylpropane-1-sulfonamide(6655-25-0)

Safety Data

• Hazardous Substances Data: 6655-25-0(Hazardous Substances Data)

Upstream product

• 10147-36-1 n-propanesulfonyl chloride 
• 62-53-3 aniline 
• 591-50-4 iodobenzene 
• 24243-71-8 propane-1-sulfonamide 

Downstream Products

• 22729-77-7 Propane-1-sulfonic acid phenyl-(1,1,2,2-tetrachloro-2-fluoro-ethylsulfanyl)-amide 

Relevant articles and documents

1,3,4-OXADIAZOLE SULFONAMIDE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to novel compounds represented by the formula I having histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel compounds. (I) The novel compounds, stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present invention have histone deacetylase (HDAC) inhibitory activity and are effective for the prevention or treatment of HDAC6-mediated diseases.

Low Catalyst Loadings for Ligand-Free Copper(I)-Oxide-Catalyzed N-Arylation of Methanesulfonamide in Water

A simple and practical protocol for the cross-coupling of methanesulfonamide and aryl iodides under ligand-free copper(I)-oxide-catalyzed conditions in water is reported. The method allows the preparation of a wide variety of synthetically useful N-arylated methanesulfonamides in good to excellent yields (up to 90 %) under the optimized conditions.