66550-08-1 Usage
Description
Quadrone is an unusual sesquiterpene metabolite isolated from Aspergillus terreus, first reported in 1978. It is known for its antitumor activity, although it has not been extensively investigated.
Uses
Used in Pharmaceutical Industry:
Quadrone is used as an antitumor agent for its potential to inhibit the growth and progression of cancer cells. Its antitumor activity makes it a promising candidate for further research and development in cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 66550-08-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,5,5 and 0 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 66550-08:
(7*6)+(6*6)+(5*5)+(4*5)+(3*0)+(2*0)+(1*8)=131
131 % 10 = 1
So 66550-08-1 is a valid CAS Registry Number.
InChI:InChI=1/C15H20O3/c1-14(2)7-15-9-4-3-8(14)10(15)5-12(16)11(15)6-18-13(9)17/h8-11H,3-7H2,1-2H3/t8-,9+,10-,11+,15-/m0/s1
66550-08-1Relevant articles and documents
THE BIOSYNTHESIS OF QUADRONE AND TERRECYCLIC ACID
Cane, David E.,Whittle, Yvonne G.,Liang, Tzyy-Chyau
, p. 1119 - 1122 (2007/10/02)
Feedings of - and acetate to Aspergillus terreus gave quadrone and terrecyclic acid which were analyzed by 13C NMR.The pattern of 13C-enrichments and couplings is consistent with the formation of 1 and 2 by cyclization of farnesyl pyrophosphate.
Total Synthesis of dl-Quadrone
Danishefsky, Samuel,Vaughan, Kenward,Gadwood, Robert C.,Tsuzuki, Kazuo
, p. 4262 - 4263 (2007/10/02)
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