66604-68-0

Basic information

• Product Name: 2,5,11-trimethyl-5a,6-dihydro-2H-pyrido[4,3-b]carbazol-6-ium iodide
• CAS NO: 66604-68-0
• Molecular Formula: C₁₈H₁₇N₂*I
• Molecular Weight: 390.2613
• Mol File: 66604-68-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 486.4°C at 760 mmHg
• Flash Point: 226.8°C
• Vapor Pressure: 1.3E-09mmHg at 25°C
• CAS DataBase Reference: 2,5,11-trimethyl-5a,6-dihydro-2H-pyrido[4,3-b]carbazol-6-ium iodide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5,11-trimethyl-5a,6-dihydro-2H-pyrido[4,3-b]carbazol-6-ium iodide(66604-68-0)
• EPA Substance Registry System: 2,5,11-trimethyl-5a,6-dihydro-2H-pyrido[4,3-b]carbazol-6-ium iodide(66604-68-0)

Safety Data

• Hazardous Substances Data: 66604-68-0(Hazardous Substances Data)

Usage

Chemical Classification

Salt

Ion Composition

Pyrido[4,3-b]carbazol-6-ium cation (positive charge) + Iodide ion (negative charge)

Derivative of

Carbazole

Structure

Heterocyclic aromatic organic compound

Properties

Unique Structure: Contains a pyrido[4,3-b]carbazol-6-ium cation, contributing to its distinct chemical properties.
Molecular Weight: Calculate using the molecular formula \textC21\textH24\textIN
Potential Applications:
Pharmaceuticals: Due to its unique structure, it may have pharmaceutical applications, potentially in drug discovery or synthesis.
Materials Science: Its distinctive properties could be utilized in materials science, possibly for developing new materials with specific characteristics.

Upstream product

• 91653-18-8 2-methyl-5-methoxycarbonyl-11-methyl-6H-pyrido[4,3-b]carbazol-2-ium iodide 
• 91653-16-6 2,11-Dimethyl-2,6-dihydro-1H-pyrido[4,3-b]carbazole-5-carboxylic acid methyl ester 
• 120-72-9 indole 
• 18028-55-2 1,4-dimethyl-9H-carbazole 
• 14501-66-7 1,4-dimethylcarbazole-3-carboxaldehyde 
• 519-23-3 ellipticine 
• 74-88-4 methyl iodide 
• 65266-47-9 N-(1,4-dimethylcarbazol-3-ylmethyl) aminoacetaldehyde diethyl acetal 

Downstream Products

• 519-23-3 ellipticine 

Relevant articles and documents

Synthesis and cytotoxicity of novel bisellipticines and bisisoellipticines

A series of bis-ellipticines 7-9 and bis-isoellipticines 10-12 tethered through the indole nitrogen was synthesized and screened for antitumor cytotoxicity in the L-1210 murine leukemia assay. Activity was only displayed by 1,10-bis(6-ellipticinyl)-?-decane (8).

Ellipticines and 9-acridinylamines as inhibitors of d-alanine:d-alanine ligase

d-Alanine:d-alanine ligase (Ddl), an intracellular bacterial enzyme essential for cell wall biosynthesis, is an attractive target for development of novel antimicrobial drugs. This study focused on an extensive evaluation of two families of Ddl inhibitors encountered in our previous research. New members of both families were obtained through similarity search and synthesis. Ellipticines and 9-acridinylamines were both found to possess inhibitory activity against Ddl from Escherichia coli and antimicrobial activity against E. coli and Staphylococcus aureus. Ellipticines with a quaternary methylpyridinium moiety were the most potent among all studied compounds, with MIC values as low as 2 mg/L in strains with intact efflux mechanisms. Antimicrobial activity of the studied compounds was connected to membrane damage, making their development as antibacterial drug candidates unlikely unless analogues devoid of this nonspecific effect can be discovered.