666180-13-8

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 4-cyano-4-[3-(cyclopentyloxy)-4-(difluoromethoxy)phenyl]-, 1,1-dimethylethyl ester
• CAS NO: 666180-13-8
• Molecular Formula: C23H30F2N2O4
• Molecular Weight: 436.499
• Mol File: 666180-13-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 4-cyano-4-[3-(cyclopentyloxy)-4-(difluoromethoxy)phenyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 4-cyano-4-[3-(cyclopentyloxy)-4-(difluoromethoxy)phenyl]-, 1,1-dimethylethyl ester(666180-13-8)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 4-cyano-4-[3-(cyclopentyloxy)-4-(difluoromethoxy)phenyl]-, 1,1-dimethylethyl ester(666180-13-8)

Safety Data

• Hazardous Substances Data: 666180-13-8(Hazardous Substances Data)

Upstream product

• 153587-15-6 (3-cyclopentyloxy-4-difluoromethoxyphenyl) acetonitrile 
• 401518-11-4 [(tert-butoxycarbonyl)imino]diethane-2,1-diyl dimethanesulfonate 
• 103898-11-9 N,N-bis(2-hydroxyethyl)-O-tert-butylcarbamate 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 401518-28-3 ethyl {4-cyano-4-[3-(cyclopentyloxy)-4-(difluoromethoxy)phenyl]piperidin-1-yl}acetate 
• 401518-45-4 {4-cyano-4-[3-(cyclopentyloxy)-4-(difluoromethoxy)phenyl]piperidine-1-yl}acetic acid 
• 577968-68-4 4-(3-cyclopentyloxy-4-difluoromethoxyphenyl)-4-cyanopiperidine 

Relevant articles and documents

Highly potent PDE4 inhibitors with therapeutic potential

Synthesis and biological evaluation of piperidine derivatives is reported. The hypothesis that the dose-limiting side effects of PDE4 inhibitors could be mediated via the central nervous system prompted us to design and synthesize a hydrophilic piperidine